Publications of the Week Engineered PLGA Microparticles for Long-Term, Pulsatile Release of STING Agonist for Cancer Immunotherapy Lu, X., et al. | August 24, 2020 STING agonist – a cancer immunotherapeutic drug – could produce strong antitumor immune responses, but…eabramovichAugust 24, 2020 Read More
Publications of the Week A Distinct Transcriptional Program in Human CAR T Cells Bearing the 4-1BB Signaling Domain Revealed by scRNA-Seq Boroughs, A.C., et al. | August 21, 2020 The authors looked at the full transcriptional profile of CAR T cells bearing different signaling…eabramovichAugust 21, 2020 Read More
Publications of the Week A Switch in p53 Dynamics Marks Cells that Escape from DSB-Induced Cell Cycle Arrest Tsabar, M., et al. | August 19, 2020 In response to DNA damage induced by ionizing irradiation, p53 undergoes oscillatory dynamics with a…eabramovichAugust 19, 2020 Read More
Publications of the Week Epigenetic Transcriptional Reprogramming by WT1 Mediates a Repair Response during Podocyte Injury Ettou, S., et al. | August 17, 2020 The authors examined transcriptional reprogramming during podocyte injury. Podocytes are crucial for maintaining filtration in…eabramovichAugust 17, 2020 Read More
Publications of the Week Epigenetic Regulator Function through Mouse Gastrulation Grosswendt, S., et al. | August 13, 2020 During ontogeny, proliferating cells become restricted in their fate through the combined action of cell-type-specific…eabramovichAugust 13, 2020 Read More
Publications of the Week Single-Cell RNA Profiling Reveals Adipocyte to Macrophage Signaling Sufficient to Enhance Thermogenesis Henriques, F., et al. | August 11, 2020 Adipocytes deficient in fatty acid synthase (iAdFASNKO) emit signals that mimic cold exposure to enhance…eabramovichAugust 11, 2020 Read More
Publications of the Week Inducible De Novo Expression of Neoantigens in Tumor Cells and Mice Damo, M., et al. | August 7, 2020 Inducible expression of neoantigens in mice would enable the study of endogenous antigen-specific naïve T…eabramovichAugust 7, 2020 Read More
Publications of the Week Regenerative Reprogramming of the Intestinal Stem Cell State via Hippo Signaling Suppresses Metastatic Colorectal Cancer Cheung, P., et al. | August 5, 2020 Although the Hippo transcriptional coactivator YAP is considered oncogenic in many tissues, its roles in…eabramovichAugust 5, 2020 Read More
Publications of the Week CRISPR C-to-G Base Editors for Inducing Targeted DNA Transversions in Human Cells Kurt, I.C., et al. | July 30, 2020 CRISPR-guided DNA cytosine and adenine base editors are widely used for many applications1,2,3,4 but primarily create…eabramovichJuly 30, 2020 Read More
Publications of the Week Dissecting Cell Type-Specific Metabolism in Pancreatic Ductal Adenocarcinoma Lau, A.N., et al. | July 28, 2020 This work provides new insight into the metabolic differences between cancer and stromal cells in…eabramovichJuly 28, 2020 Read More