Publications of the Week All-Optical Electrophysiology Reveals the Role of Lateral Inhibition in Sensory Processing in Cortical Layer 1Fan, L., Z., et al. | February 13, 2020Cortical layer 1 (L1) interneurons have been proposed as a hub for attentional modulation of…sciencecityFebruary 13, 2020 Read More
Publications of the Week Aneuploidy and a Deregulated DNA Damage Response Suggest Haploinsufficiency in Breast Tissues of BRCA2 Mutation CarriersKaraayvaz-Yildirim, M., et al. | February 11, 2020Women harboring heterozygous germline mutations of BRCA2 have a 50 to 80% risk of developing…sciencecityFebruary 11, 2020 Read More
Publications of the Week Antioxidant CoQ10 Restores Fertility by Rescuing Bisphenol A-Induced Oxidative DNA Damage in the Caenorhabditis Elegans GermlineCarneiro, M., et al. | February 10, 2020Endocrine-disrupting chemicals are ubiquitously present in our environment, but the mechanisms by which they adversely…sciencecityFebruary 10, 2020 Read More
Publications of the Week Genome-Wide In Vivo CNS Screening Identifies Genes That Modify CNS Neuronal Survival and mHTT ToxicityWertz, M., H., et al. | February 6, 2020Unbiased in vivo genome-wide genetic screening is a powerful approach to elucidate new molecular mechanisms, but such screening…sciencecityFebruary 6, 2020 Read More
Publications of the Week Cell Release during Perfusion Reflects Cold Ischemic Injury in Rat Liversde Vries., R., J., et al. | February 6, 2020The global shortage of donor organs has made it crucial to deeply understand and better…sciencecityFebruary 6, 2020 Read More
Publications of the Week A Model for the Emergence of RNA from a Prebiotically Plausible Mixture of Ribonucleotides, Arabinonucleotides, and 2′-DeoxynucleotidesKim, S., C., et al. | January 31, 2020The abiotic synthesis of ribonucleotides is thought to have been an essential step toward the…sciencecityJanuary 31, 2020 Read More
Publications of the Week Compression-Induced Dedifferentiation of Adipocytes Promotes Tumor ProgressionLi, et al. | January 29, 2020Dysregulated physical stresses are generated during tumorigenesis that affect the surrounding compliant tissues including adipocytes.…sciencecityJanuary 29, 2020 Read More
Publications of the Week Structure-Guided Design of Pure Orthosteric Inhibitors of αIIbβ3 That Prevent Thrombosis but Preserve HemostasisAdair, B., D., et al. | January 24, 2020A prevailing dogma is that inhibition of vascular thrombosis by antagonizing platelet integrin αIIbβ3 cannot…sciencecityJanuary 24, 2020 Read More
Publications of the Week Hyperactivation of Sympathetic Nerves Drives Depletion of Melanocyte Stem CellsZhang, B., et al. | January 23, 2020Empirical and anecdotal evidence has associated stress with accelerated hair greying (formation of unpigmented hairs),…sciencecityJanuary 23, 2020 Read More
Publications of the Week Mechanism of Adrenergic CaV1.2 Stimulation Revealed by Proximity ProteomicsLiu, G., et al. | January 23, 2020Increased cardiac contractility during the fight-or-flight response is caused by β-adrenergic augmentation of CaV1.2 voltage-gated…sciencecityJanuary 23, 2020 Read More