Publications of the Week Targeting the HIF2–VEGF Axis in Renal Cell Carcinoma Choueiri, T.K., & Kaelin Jr., W.G. | October 9, 2020 Insights into the role of the tumor suppressor pVHL in oxygen sensing motivated the testing…eabramovichOctober 9, 2020 Read More
Publications of the Week Divergent Roles of PI3K Isoforms in PTEN-Deficient Glioblastomas Xie, S., et al. | October 8, 2020 Loss of PTEN, the negative regulator of PI3K activity, is frequent in glioblastomas (GBMs). However,…eabramovichOctober 8, 2020 Read More
Publications of the Week pH-Gated Succinate Secretion Regulates Muscle Remodeling in Response to Exercise Reddy, A., et al. | October 1, 2020 The authors discovered that exercising muscle selectively releases the mitochondrial metabolite succinate. Once released, succinate…eabramovichOctober 1, 2020 Read More
Publications of the Week HDAC6 Mediates an Aggresome-Like Mechanism for NLRP3 and Pyrin Inflammasome Activation Magupalli, V.G., et al. | September 28, 2020 Canonical inflammasomes are multicomponent protein complexes that play key roles in immune surveillance of infections…eabramovichSeptember 28, 2020 Read More
Publications of the Week A Regulatory T Cell Notch4–GDF15 Axis Licenses Tissue Inflammation in Asthma Harb, H., et al. | September 24, 2020 This study provides a comprehensive framework for understanding inflammation in asthma. The authors identified a…eabramovichSeptember 24, 2020 Read More
Publications of the Week Antibiotic Susceptibility Signatures Identify Potential Antimicrobial Targets in the Acinetobacter baumannii Cell Envelope Geisinger, E., et al. | September 23, 2020 A unique, protective cell envelope contributes to the broad drug resistance of the nosocomial pathogen Acinetobacter…eabramovichSeptember 23, 2020 Read More
Publications of the Week CSF1R Inhibition by a Small-Molecule Inhibitor Is Not Microglia Specific; Affecting Hematopoiesis and the Function of Macrophages Lei, F., et al. | September 16, 2020 Colony-stimulating factor 1 receptor (CSF1R) inhibition has been extensively adopted by many laboratories for the…eabramovichSeptember 16, 2020 Read More
Publications of the Week Cell-Based Artificial APC Resistant to Lentiviral Transduction for Efficient Generation of CAR-T Cells from Various Cell Sources Schmidts, A., et al. | September 14, 2020 Adoptive cell therapy with chimeric antigen receptor T cells (CAR-T) has become a standard treatment…eabramovichSeptember 14, 2020 Read More
Publications of the Week STING Cyclic Dinucleotide Sensing Originated in Bacteria Morehouse, B.R., et al. | September 11, 2020 Stimulator of interferon genes (STING) is a receptor in human cells that senses foreign cyclic…eabramovichSeptember 11, 2020 Read More
Publications of the Week Ultra-Sensitive Serial Profiling of SARS-CoV-2 Antigens and Antibodies in Plasma to Understand Disease Progression in COVID-19 Patients with Severe Disease Ogata, A.F., et al. | September 9, 2020 Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has infected over 21 million people worldwide since…eabramovichSeptember 9, 2020 Read More