Publications of the Week Drug GRADE: An Integrated Analysis of Population Growth and Cell Death Reveals Drug-Specific and Cancer Subtype-Specific Response ProfilesSchwartz, H.R., et al. | June 29, 2020The typical measurement for evaluating drugs doesn’t distinguish between responses that are due to inhibition…eabramovichJune 29, 2020 Read More
Publications of the Week cGMP via PKG Activates 26S Proteasomes and Enhances Degradation of Proteins, Including Ones that Cause Neurodegenerative DiseasesVerPlank, J.J.S., et al. | June 26, 2020The authors demonstrate that agents that raise cGMP and activate the cGMP-dependent protein kinase (PKG),…eabramovichJune 26, 2020 Read More
Publications of the Week Inhibition of the Translesion Synthesis Polymerase REV1 Exploits Replication Gaps as a Cancer VulnerabilityNayak, S., et al. | June 22, 2020The authors reveal how a well described anti-cancer barrier, “the replication stress response,” is overcome…eabramovichJune 22, 2020 Read More
Publications of the Week Keap1 Mutation Renders Lung Adenocarcinomas Dependent on Slc33a1Romero, R., et al. | June 19, 2020Approximately 20–30% of human lung adenocarcinomas (LUADs) harbor mutations in Kelch-like ECH-associated protein 1 (KEAP1)…eabramovichJune 19, 2020 Read More
Publications of the Week Previremic Identification of Ebola or Marburg Virus Infection Using Integrated Host-Transcriptome and Viral Genome DetectionSperanza, E., et al. | June 18, 2020Outbreaks of filoviruses, such as those caused by the Ebola (EBOV) and Marburg (MARV) virus,…eabramovichJune 18, 2020 Read More
Publications of the Week Maternal H3K27me3-Dependent Autosomal and X Chromosome ImprintingChen, Z., & Zhang, Y. | June 12, 2020Genomic imprinting and X-chromosome inactivation (XCI) are classic epigenetic phenomena that involve transcriptional silencing of…eabramovichJune 12, 2020 Read More
Publications of the Week The Perlman Syndrome DIS3L2 Exoribonuclease Safeguards Endoplasmic Reticulum-Targeted mRNA Translation and Calcium Ion HomeostasisPirouz, M., et al. | June 9, 2020DIS3L2-mediated decay (DMD) is a surveillance pathway for certain non-coding RNAs (ncRNAs) including ribosomal RNAs…eabramovichJune 9, 2020 Read More
Publications of the Week Hair-Bearing Human Skin Generated Entirely from Pluripotent Stem CellsLee, J., et al. | June 5, 2020The skin is a multilayered organ, equipped with appendages (that is, follicles and glands), that…eabramovichJune 5, 2020 Read More
Publications of the Week Loss of Heterozygosity of Essential Genes Represents a Widespread Class of Potential Cancer VulnerabilitiesNichols, C.A., et al. | June 1, 2020About one out of every six genes loses one of its two alleles in the…eabramovichJune 1, 2020 Read More
Publications of the Week Transcriptional and Cellular Diversity of the Human HeartTucker, N.R., et al. | May 28, 2020The human heart requires a complex ensemble of specialized cell types to perform its essential…eabramovichMay 28, 2020 Read More