Publications of the Week Parallel Single-Cell RNA-Seq and Genetic Recording Reveals Lineage Decisions in Developing Embryoid Bodies Kim, I.S., et al. | October 21, 2020 Early developmental specification can be modeled by differentiating embryonic stem cells (ESCs) to embryoid bodies…eabramovichOctober 21, 2020 Read More
Publications of the Week A Stearoyl-CoA Desaturase Inhibitor Prevents Multiple Parkinson’s Disease-Phenotypes in α-Synuclein Mice Nuber, S., et al. | October 14, 2020 The α-synuclein protein accumulates in Parkinson’s disease and other synucleinopathies. Growing evidence suggests that lipid-rich…eabramovichOctober 14, 2020 Read More
Publications of the Week Association of Caffeine and Related Analytes with Resistance to Parkinson’s Disease among LRRK2 Mutation Carriers: A Metabolomic Study Crotty, G. F., et al. | October 12, 2020 This study observed that caffeine and its related analytes were lower in individuals with Parkinson's…eabramovichOctober 12, 2020 Read More
Publications of the Week Targeting the HIF2–VEGF Axis in Renal Cell Carcinoma Choueiri, T.K., & Kaelin Jr., W.G. | October 9, 2020 Insights into the role of the tumor suppressor pVHL in oxygen sensing motivated the testing…eabramovichOctober 9, 2020 Read More
Publications of the Week Divergent Roles of PI3K Isoforms in PTEN-Deficient Glioblastomas Xie, S., et al. | October 8, 2020 Loss of PTEN, the negative regulator of PI3K activity, is frequent in glioblastomas (GBMs). However,…eabramovichOctober 8, 2020 Read More
Publications of the Week pH-Gated Succinate Secretion Regulates Muscle Remodeling in Response to Exercise Reddy, A., et al. | October 1, 2020 The authors discovered that exercising muscle selectively releases the mitochondrial metabolite succinate. Once released, succinate…eabramovichOctober 1, 2020 Read More
Publications of the Week HDAC6 Mediates an Aggresome-Like Mechanism for NLRP3 and Pyrin Inflammasome Activation Magupalli, V.G., et al. | September 28, 2020 Canonical inflammasomes are multicomponent protein complexes that play key roles in immune surveillance of infections…eabramovichSeptember 28, 2020 Read More
Publications of the Week A Regulatory T Cell Notch4–GDF15 Axis Licenses Tissue Inflammation in Asthma Harb, H., et al. | September 24, 2020 This study provides a comprehensive framework for understanding inflammation in asthma. The authors identified a…eabramovichSeptember 24, 2020 Read More
Publications of the Week Antibiotic Susceptibility Signatures Identify Potential Antimicrobial Targets in the Acinetobacter baumannii Cell Envelope Geisinger, E., et al. | September 23, 2020 A unique, protective cell envelope contributes to the broad drug resistance of the nosocomial pathogen Acinetobacter…eabramovichSeptember 23, 2020 Read More
Publications of the Week CSF1R Inhibition by a Small-Molecule Inhibitor Is Not Microglia Specific; Affecting Hematopoiesis and the Function of Macrophages Lei, F., et al. | September 16, 2020 Colony-stimulating factor 1 receptor (CSF1R) inhibition has been extensively adopted by many laboratories for the…eabramovichSeptember 16, 2020 Read More