Publications of the Week NHR-49/PPAR-α and HLH-30/TFEB Cooperate for C. elegans Host Defense via a Flavin-Containing Monooxygenase Wani, K. A., et al. | May 26, 2021 The model organism Caenorhabditis elegans mounts transcriptional defense responses against intestinal bacterial infections that elicit…pthomsonMay 26, 2021 Read More
Publications of the Week Therapeutically Reprogrammed Nutrient Signaling Enhances Nanoparticulate Albumin Bound Drug Uptake and Efficacy in KRAS-Mutant Cancer Li, R., et al. | May 21, 2021 Nanoparticulate albumin bound paclitaxel (nab-paclitaxel, nab-PTX) is among the most widely prescribed nanomedicines in clinical…pthomsonMay 21, 2021 Read More
Publications of the Week Extended-Representation Bisulfite Sequencing of Gene Regulatory Elements in Multiplexed Samples and Single Cells Shareef, S. J., et al. | May 20, 2021 The biological roles of DNA methylation have been elucidated by profiling methods based on whole-genome…pthomsonMay 20, 2021 Read More
Publications of the Week O-GlcNAc Modification of Nuclear Pore Complexes Accelerates Bidirectional Transport Yoo, T. Y. & Mitchison, T. J. | May 12, 2021 Macromolecular transport across the nuclear envelope depends on facilitated diffusion through nuclear pore complexes (NPCs).…pthomsonMay 12, 2021 Read More
Publications of the Week ZNF410 Represses Fetal Globin by Singular Control of CHD4 Vinjamur, D. S., et al. | May 10, 2021 This week we profile a recent publication in Nature Genetics from Dr. Divya Vinjamur in…pthomsonMay 10, 2021 Read More
Publications of the Week ATRX Limits the Accessibility of Histone H3-Occupied HSV Genomes during Lytic Infection Cabral, J. M., et al. | May 7, 2021 Histones are rapidly loaded on the HSV genome upon entry into the nucleus of human…pthomsonMay 7, 2021 Read More
Publications of the Week Suppression of Pancreatic Ductal Adenocarcinoma Growth and Metastasis by Fibrillar Collagens Produced Selectively by Tumor Cells Tian, C., et al. | May 4, 2021 Pancreatic ductal adenocarcinoma (PDAC) has a collagen-rich dense extracellular matrix (ECM) that promotes malignancy of…pthomsonMay 4, 2021 Read More
Publications of the Week Gasdermin D Pore Structure Reveals Preferential Release of Mature Interleukin-1 Xia, S., et al. | April 30, 2021 As organelles of the innate immune system, inflammasomes activate caspase-1 and other inflammatory caspases that…pthomsonApril 30, 2021 Read More
Publications of the Week Single-Cell Analysis of FOXP3 Deficiencies in Humans and Mice Unmasks Intrinsic and Extrinsic CD4+ T Cell Perturbations Zemmour, D., et al. | April 26, 2021 FOXP3 deficiency in mice and in patients with immune dysregulation polyendocrinopathy enteropathy X-linked (IPEX) syndrome results…pthomsonApril 26, 2021 Read More
Publications of the Week Shutoff of Host Transcription Triggers a Toxin-Antitoxin System to Cleave Phage RNA and Abort Infection Guegler, C. K., et al. | April 23, 2021 Toxin-antitoxin (TA) systems are widespread in bacteria, but their activation mechanisms and bona fide targets…pthomsonApril 23, 2021 Read More