Publications of the Week Aneuploidy and a Deregulated DNA Damage Response Suggest Haploinsufficiency in Breast Tissues of BRCA2 Mutation Carriers Karaayvaz-Yildirim, M., et al. | February 11, 2020 Women harboring heterozygous germline mutations of BRCA2 have a 50 to 80% risk of developing…sciencecityFebruary 11, 2020 Read More
Publications of the Week Antioxidant CoQ10 Restores Fertility by Rescuing Bisphenol A-Induced Oxidative DNA Damage in the Caenorhabditis Elegans Germline Carneiro, M., et al. | February 10, 2020 Endocrine-disrupting chemicals are ubiquitously present in our environment, but the mechanisms by which they adversely…sciencecityFebruary 10, 2020 Read More
Publications of the Week Genome-Wide In Vivo CNS Screening Identifies Genes That Modify CNS Neuronal Survival and mHTT Toxicity Wertz, M., H., et al. | February 6, 2020 Unbiased in vivo genome-wide genetic screening is a powerful approach to elucidate new molecular mechanisms, but such screening…sciencecityFebruary 6, 2020 Read More
Publications of the Week Cell Release during Perfusion Reflects Cold Ischemic Injury in Rat Livers de Vries., R., J., et al. | February 6, 2020 The global shortage of donor organs has made it crucial to deeply understand and better…sciencecityFebruary 6, 2020 Read More
Publications of the Week A Model for the Emergence of RNA from a Prebiotically Plausible Mixture of Ribonucleotides, Arabinonucleotides, and 2′-Deoxynucleotides Kim, S., C., et al. | January 31, 2020 The abiotic synthesis of ribonucleotides is thought to have been an essential step toward the…sciencecityJanuary 31, 2020 Read More
Publications of the Week Compression-Induced Dedifferentiation of Adipocytes Promotes Tumor Progression Li, et al. | January 29, 2020 Dysregulated physical stresses are generated during tumorigenesis that affect the surrounding compliant tissues including adipocytes.…sciencecityJanuary 29, 2020 Read More
Publications of the Week Structure-Guided Design of Pure Orthosteric Inhibitors of αIIbβ3 That Prevent Thrombosis but Preserve Hemostasis Adair, B., D., et al. | January 24, 2020 A prevailing dogma is that inhibition of vascular thrombosis by antagonizing platelet integrin αIIbβ3 cannot…sciencecityJanuary 24, 2020 Read More
Publications of the Week Hyperactivation of Sympathetic Nerves Drives Depletion of Melanocyte Stem Cells Zhang, B., et al. | January 23, 2020 Empirical and anecdotal evidence has associated stress with accelerated hair greying (formation of unpigmented hairs),…sciencecityJanuary 23, 2020 Read More
Publications of the Week Mechanism of Adrenergic CaV1.2 Stimulation Revealed by Proximity Proteomics Liu, G., et al. | January 23, 2020 Increased cardiac contractility during the fight-or-flight response is caused by β-adrenergic augmentation of CaV1.2 voltage-gated…sciencecityJanuary 23, 2020 Read More
Publications of the Week Increased Expression of Schizophrenia-Associated Gene C4 Leads to Hypoconnectivity of Prefrontal Cortex and Reduced Social Interaction Comer, A., L., et al. | January 22, 2020 Schizophrenia is a severe mental disorder with an unclear pathophysiology. Increased expression of the immune…sciencecityJanuary 22, 2020 Read More