Publications of the Week

The HOXA gene locus coordinates body patterning, hematopoiesis, and differentiation. While studying blood phenotype-associated variation…

Barrier organs rely on a limited set of pattern recognition receptors (PRRs) to detect diverse…

Dravet syndrome (DS) is a severe genetic developmental and epileptic encephalopathy usually resulting from mutations…

Three-dimensional genome organization underlies gene regulation, yet how acute hormonal signalling reshapes chromatin structure to…

Transcription reshapes DNA folding within living cells, driving patterns of gene expression. However, this process…

Targeted insertion of large DNA fragments has promising applications for genome engineering and gene therapy1,2.…

Chromatin dynamics control the timescales of essential biological processes and reflect how chromatin is organized…

Cancer-causing mutations have been identified primarily from positive selection signals in cancer genomes. However, positive…

Human cerebral organoids derived from induced pluripotent stem cells can recapture early developmental processes and…

Engineered virus-like particles (eVLPs) are promising vehicles for transient delivery of gene editing agents. While…