Publications of the Week High-Throughput Evaluation of Genetic Variants with Prime Editing Sensor LibrariesGould, S., et al. | March 15, 2024Tumor genomes often harbor a complex spectrum of single nucleotide alterations and chromosomal rearrangements that…karnottMarch 15, 2024 Read More
Publications of the Week Single Nuclei Transcriptomics in Human and Non-Human Primate Striatum in Opioid Use DisorderPhan, B., et al. | March 11, 2024In brain, the striatum is a heterogenous region involved in reward and goal-directed behaviors. Striatal…karnottMarch 11, 2024 Read More
Publications of the Week Proteogenomic Characterization of Primary Colorectal Cancer and Metastatic Progression Identifies Proteome-Based Subtypes and SignaturesTanaka, A., et al. | March 8, 2024Metastatic progression of colorectal adenocarcinoma (CRC) remains poorly understood and poses significant challenges for treatment.…karnottMarch 8, 2024 Read More
Publications of the Week SOX17 Enables Immune Evasion of Early Colorectal Adenomas and CancersGoto, N., et al. | March 6, 2024A hallmark of cancer is the avoidance of immune destruction. This process has been primarily…karnottMarch 6, 2024 Read More
Publications of the Week Genetic Drivers of Heterogeneity in Type 2 Diabetes PathophysiologySuzuki, K., et al. | March 4, 2024Type 2 diabetes (T2D) is a heterogeneous disease that develops through diverse pathophysiological processes1,2 and…karnottMarch 4, 2024 Read More
Publications of the Week Distinct Negative Elongation Factor Conformations Regulate RNA Polymerase II Promoter-Proximal PausingSu, B., et al. | March 1, 2024Metazoan gene expression regulation involves pausing of RNA polymerase (Pol II) in the promoter-proximal region…karnottMarch 1, 2024 Read More
Publications of the Week Integrative Analyses of Tumor and Peripheral Biomarkers in the Treatment of Advanced Renal Cell CarcinomaChoueiri, T., et al. | February 28, 2024The phase III JAVELIN Renal 101 trial demonstrated prolonged progression-free survival (PFS) in patients (N = 886)…karnottFebruary 28, 2024 Read More
Publications of the Week Genetic Architecture and Biology of Youth-Onset Type 2 DiabetesKwak, S., et al. | February 26, 2024The prevalence of youth-onset type 2 diabetes (T2D) and childhood obesity has been rising steadily1,…karnottFebruary 26, 2024 Read More
Publications of the Week Capivasertib Combines with Docetaxel to Enhance Anti-Tumour Activity Through Inhibition of AKT-Mediated Survival Mechanisms in Prostate CancerEberlein, C., et al. | February 23, 2024Combining docetaxel and capivasertib had increased activity in PTEN null and WT prostate tumour models…karnottFebruary 23, 2024 Read More
Publications of the Week Genome-Wide Association Study Identifies Human Genetic Variants Associated with Fatal Outcome from Lassa FeverKotliar, D., et al. | February 19, 2024Infection with Lassa virus (LASV) can cause Lassa fever, a haemorrhagic illness with an estimated…karnottFebruary 19, 2024 Read More