Publications of the Week

Mitochondria play a vital role in cellular energy metabolism and vascular health, with their function…

Aortic aneurysms are potentially fatal focal enlargements of the aortic lumen; the disease burden is…

Repeat element viral mimicry is a common feature in pancreatic ductal adenocarcinoma (PDAC) that requires…

A major contributor to poor sensitivity to anti-cancer kinase inhibitor therapy is drug-induced cellular adaptation,…

Integrator (INT) is a metazoan-specific complex that targets promoter-proximally paused RNA polymerase II (RNAPII) for…

The composition and organization of the cell surface determine how cells interact with their environment.…

In a therapeutic context, supraphysiological expression of transgenes can compromise engineered phenotypes and lead to…

Among patients with advanced non–small cell lung cancer (NSCLC) who discontinue immune checkpoint inhibitors (ICI)…

Despite harboring the highest tumor mutational burden of all cancers, basal cell carcinoma (BCC) has…

Structural maintenance of chromosomes (SMC) protein complexes, which include cohesin and condensin, play crucial roles…