Publications of the Week O-GlcNAc Modification of Nuclear Pore Complexes Accelerates Bidirectional Transport Yoo, T. Y. & Mitchison, T. J. | May 12, 2021 Macromolecular transport across the nuclear envelope depends on facilitated diffusion through nuclear pore complexes (NPCs).…pthomsonMay 12, 2021 Read More
Publications of the Week ZNF410 Represses Fetal Globin by Singular Control of CHD4 Vinjamur, D. S., et al. | May 10, 2021 This week we profile a recent publication in Nature Genetics from Dr. Divya Vinjamur in…pthomsonMay 10, 2021 Read More
Publications of the Week ATRX Limits the Accessibility of Histone H3-Occupied HSV Genomes during Lytic Infection Cabral, J. M., et al. | May 7, 2021 Histones are rapidly loaded on the HSV genome upon entry into the nucleus of human…pthomsonMay 7, 2021 Read More
Publications of the Week Suppression of Pancreatic Ductal Adenocarcinoma Growth and Metastasis by Fibrillar Collagens Produced Selectively by Tumor Cells Tian, C., et al. | May 4, 2021 Pancreatic ductal adenocarcinoma (PDAC) has a collagen-rich dense extracellular matrix (ECM) that promotes malignancy of…pthomsonMay 4, 2021 Read More
Publications of the Week Gasdermin D Pore Structure Reveals Preferential Release of Mature Interleukin-1 Xia, S., et al. | April 30, 2021 As organelles of the innate immune system, inflammasomes activate caspase-1 and other inflammatory caspases that…pthomsonApril 30, 2021 Read More
Publications of the Week Single-Cell Analysis of FOXP3 Deficiencies in Humans and Mice Unmasks Intrinsic and Extrinsic CD4+ T Cell Perturbations Zemmour, D., et al. | April 26, 2021 FOXP3 deficiency in mice and in patients with immune dysregulation polyendocrinopathy enteropathy X-linked (IPEX) syndrome results…pthomsonApril 26, 2021 Read More
Publications of the Week Shutoff of Host Transcription Triggers a Toxin-Antitoxin System to Cleave Phage RNA and Abort Infection Guegler, C. K., et al. | April 23, 2021 Toxin-antitoxin (TA) systems are widespread in bacteria, but their activation mechanisms and bona fide targets…pthomsonApril 23, 2021 Read More
Publications of the Week The MicroRNA miR-696 is Regulated by SNARK and Reduces Mitochondrial Activity in Mouse Skeletal Muscle Through Pgc1α Inhibition Queiroz, A.L., et al. | April 20, 2021 MicroRNAs (miRNA) are known to regulate expression of genes involved in several physiological processes including…pthomsonApril 20, 2021 Read More
Publications of the Week Chemokines and the Immune Response to Cancer Ozga, A. J., et al. | April 16, 2021 Chemokines are chemotactic cytokines that regulate the migration of immune cells. Chemokines function as cues…pthomsonApril 16, 2021 Read More
Publications of the Week A RIPK1-Regulated Inflammatory Microglial State in Amyotrophic Lateral Sclerosis Mifflin, L., et al. | April 14, 2021 Microglial-derived inflammation has been linked to a broad range of neurodegenerative and neuropsychiatric conditions, including…pthomsonApril 14, 2021 Read More