Publications of the Week STAG2 Loss Rewires Oncogenic and Developmental Programs to Promote Metastasis in Ewing Sarcoma Adane, B., et al. | June 17, 2021 The core cohesin subunit STAG2 is recurrently mutated in Ewing sarcoma but its biological role…sciencecityJune 17, 2021 Read More
Publications of the Week Cis P-Tau Underlies Vascular Contribution to Cognitive Impairment and Dementia and Can Be Effectively Targeted by Immunotherapy in Mice Qiu, C., et al. | June 11, 2021 Vascular contributions to cognitive impairment and dementia (VCID) are conditions arising from vascular diseases or…pthomsonJune 11, 2021 Read More
Publications of the Week Ku70 Suppresses Alternative End Joining in G1-Arrested Progenitor B Cells Liang, Z., et al. | June 8, 2021 This week we profile a recent publication in PNAS from Dr. Frederick Alt's lab at…pthomsonJune 8, 2021 Read More
Publications of the Week Acute Pharmacological Degradation of Helios Destabilizes Regulatory T Cells Wang, E. S., Verano, A., Nowak, R., & Yuan, J. C., et al. | June 4, 2021 The zinc-finger transcription factor Helios is critical for maintaining the identity, anergic phenotype and suppressive…pthomsonJune 4, 2021 Read More
Publications of the Week 16p11.2 Deletion Is Associated with Hyperactivation of Human iPSC-Derived Dopaminergic Neuron Networks and Is Rescued by RHOA Inhibition In Vitro Sundberg, M., et al. | May 28, 2021 Reciprocal copy number variations (CNVs) of 16p11.2 are associated with a wide spectrum of neuropsychiatric…pthomsonMay 28, 2021 Read More
Publications of the Week NHR-49/PPAR-α and HLH-30/TFEB Cooperate for C. elegans Host Defense via a Flavin-Containing Monooxygenase Wani, K. A., et al. | May 26, 2021 The model organism Caenorhabditis elegans mounts transcriptional defense responses against intestinal bacterial infections that elicit…pthomsonMay 26, 2021 Read More
Publications of the Week Therapeutically Reprogrammed Nutrient Signaling Enhances Nanoparticulate Albumin Bound Drug Uptake and Efficacy in KRAS-Mutant Cancer Li, R., et al. | May 21, 2021 Nanoparticulate albumin bound paclitaxel (nab-paclitaxel, nab-PTX) is among the most widely prescribed nanomedicines in clinical…pthomsonMay 21, 2021 Read More
Publications of the Week Extended-Representation Bisulfite Sequencing of Gene Regulatory Elements in Multiplexed Samples and Single Cells Shareef, S. J., et al. | May 20, 2021 The biological roles of DNA methylation have been elucidated by profiling methods based on whole-genome…pthomsonMay 20, 2021 Read More
Publications of the Week O-GlcNAc Modification of Nuclear Pore Complexes Accelerates Bidirectional Transport Yoo, T. Y. & Mitchison, T. J. | May 12, 2021 Macromolecular transport across the nuclear envelope depends on facilitated diffusion through nuclear pore complexes (NPCs).…pthomsonMay 12, 2021 Read More
Publications of the Week ZNF410 Represses Fetal Globin by Singular Control of CHD4 Vinjamur, D. S., et al. | May 10, 2021 This week we profile a recent publication in Nature Genetics from Dr. Divya Vinjamur in…pthomsonMay 10, 2021 Read More