Publications of the Week LSD1 Inhibition Sustains T Cell Invigoration with a Durable Response to PD-1 Blockade Liu, Y., et al. | December 10, 2021 Exhausted CD8+ T cells are key targets of immune checkpoint blockade therapy and their ineffective reinvigoration…pthomsonDecember 10, 2021 Read More
Publications of the Week Microenvironment Drives Cell State, Plasticity, and Drug Response in Pancreatic Cancer Raghavan, S., et al. | December 8, 2021 Prognostically relevant RNA expression states exist in pancreatic ductal adenocarcinoma (PDAC), but our understanding of…pthomsonDecember 8, 2021 Read More
Publications of the Week Glucose Metabolism and Pyruvate Carboxylase Enhance Glutathione Synthesis and Restrict Oxidative Stress in Pancreatic Islets Fu, A., et al. | December 3, 2021 Glucose metabolism modulates the islet β cell responses to diabetogenic stress, including inflammation. Here, we…pthomsonDecember 3, 2021 Read More
Publications of the Week Intercellular Nanotubes Mediate Mitochondrial Trafficking between Cancer and Immune Cells Saha, T., et al. | December 2, 2021 Cancer progresses by evading the immune system. Elucidating diverse immune evasion strategies is a critical…pthomsonDecember 2, 2021 Read More
Publications of the Week Reprogramming NK Cells and Macrophages via Combined Antibody and Cytokine Therapy Primes Tumors for Elimination by Checkpoint Blockade Wang, C., et al. | November 26, 2021 Treatments aiming to augment immune checkpoint blockade (ICB) in cancer often focus on T cell immunity,…pthomsonNovember 26, 2021 Read More
Publications of the Week A Tissue-Bioengineering Strategy for Modeling Rare Human Kidney Diseases In Vivo Hernandez, J. O. R., & Wang, X., et al. | November 22, 2021 A recent publication in Nature Communications showcases a bioengineering approach to model renal diseases associated…pthomsonNovember 22, 2021 Read More
Publications of the Week Sensory Transduction Is Required for Normal Development and Maturation of Cochlear Inner Hair Cell Synapses Lee, J., et al. | November 19, 2021 Acoustic overexposure and aging can damage auditory synapses in the inner ear by a process…pthomsonNovember 19, 2021 Read More
Publications of the Week Indoleamine 2,3-dioxygenase-1, a Novel Therapeutic Target for Post-Vascular Injury Thrombosis in CKD Walker, J. A., et al. | November 15, 2021 CKD, characterized by retained uremic solutes, is a strong and independent risk factor for thrombosis…pthomsonNovember 15, 2021 Read More
Publications of the Week Inner Nuclear Protein Matrin-3 Coordinates Cell Differentiation by Stabilizing Chromatin Architecture Cha, H. J., et al. | November 12, 2021 Precise control of gene expression during differentiation relies on the interplay of chromatin and nuclear…pthomsonNovember 12, 2021 Read More
Publications of the Week Lung Proteomic Biomarkers Associated with Chronic Obstructive Pulmonary Disease Zyang. Y.-H., et al. | November 8, 2021 Identifying protein biomarkers for chronic obstructive pulmonary disease (COPD) has been challenging. Most previous studies…pthomsonNovember 8, 2021 Read More