Publications of the Week Regulatory Genomic Circuitry of Human Disease Loci by Integrative Epigenomics Boix, C., et al. | February 10, 2021 Annotating the molecular basis of human disease remains an unsolved challenge, as 93% of disease…sciencecityFebruary 10, 2021 Read More
Publications of the Week Tripartite Motif 22 (TRIM22) Protein Restricts Herpes Simplex Virus 1 by Epigenetic Silencing of Viral Immediate-Early Genes Reddi, T., et al. | February 9, 2021 The Knipe laboratory studies the mechanisms by which herpes simplex virus (HSV) undergoes a productive…emcguinnFebruary 9, 2021 Read More
Publications of the Week Opposing Immune and Genetic Mechanisms Shape Oncogenic Programs in Synovial Sarcoma Jerbyn-Arnon, L., et al. | February 5, 2021 Synovial sarcoma (SyS) is an aggressive neoplasm driven by the SS18–SSX fusion, and is characterized…emcguinnFebruary 5, 2021 Read More
Publications of the Week Targeting a BRAF/MAPK Pathway Rescues Podocyte Lipid Peroxidation in CoQ Deficiency Kidney Disease Sidhom, E., et al. | February 1, 2021 Mutations affecting mitochondrial coenzyme Q (CoQ) biosynthesis lead to kidney failure due to selective loss…emcguinnFebruary 1, 2021 Read More
Publications of the Week Cryo-EM Structure of the B Cell Co-Receptor CD19 Bound to the Tetraspanin CD81 Susa, K., et al. | January 28, 2021 Signaling through the CD19-CD81 co-receptor complex, in combination with the B cell receptor, is a…emcguinnJanuary 28, 2021 Read More
Publications of the Week Single-Cell Lineages Reveal the Rates, Routes, and Drivers of Metastasis in Cancer Xenografts Quinn, J., et al. | January 28, 2021 Detailed phylogenies of tumor populations can recount the history and chronology of critical events during…emcguinnJanuary 28, 2021 Read More
Publications of the Week Beyond Conventional Immune-Checkpoint Inhibition — Novel Immunotherapies for Renal Cell Carcinoma Braun, D., et al. | January 25, 2021 The management of advanced-stage renal cell carcinoma (RCC) has been transformed by the development of…emcguinnJanuary 25, 2021 Read More
Publications of the Week Human Endothelial Colony-Forming Cells Provide Trophic Support for Pluripotent Stem Cell-Derived Cardiomyocytes via Distinctively High Expression of Neuregulin-1 Hong, X., et al. | January 20, 2021 The search for a source of endothelial cells (ECs) with translational therapeutic potential remains crucial…eabramovichJanuary 20, 2021 Read More
Publications of the Week A Microbial Metabolite Remodels the Gut-Liver Axis following Bariatric Surgery Chaudhari, S.N., et al. | January 18, 2021 Bariatric surgery is the most effective treatment for type 2 diabetes and is associated with…eabramovichJanuary 18, 2021 Read More
Publications of the Week Gut-Licensed IFNγ+ NK Cells Drive LAMP1+TRAIL+ Anti-Inflammatory Astrocytes Sanmarco, L.M., et al. | January 15, 2021 Astrocytes are glial cells that are abundant in the central nervous system (CNS) and that…eabramovichJanuary 15, 2021 Read More