Publications of the Week cGAS-Like Receptors Sense RNA and Control 3′2′-cGAMP Signaling in Drosophila Slavik, K. M., et al. | July 27, 2021 Cyclic GMP–AMP synthase (cGAS) is a cytosolic DNA sensor that produces the second messenger 2′3′-cGAMP…pthomsonJuly 27, 2021 Read More
Publications of the Week Extracellular Domain Shedding of the ALK Receptor Mediates Neuroblastoma Cell Migration Huang, H., et al. | July 22, 2021 Although activating mutations of the anaplastic lymphoma kinase (ALK) membrane receptor occur in ∼10% of…pthomsonJuly 22, 2021 Read More
Publications of the Week Haplotype-Resolved Germline and Somatic Alterations in Renal Medullary Carcinomas Tan, K.-T., et al. | July 21, 2021 Renal medullary carcinomas (RMCs) are rare kidney cancers that occur in adolescents and young adults…pthomsonJuly 21, 2021 Read More
Publications of the Week Actin-Related Protein (Arp) 2/3 Complex Plays a Critical Role in the Aquaporin-2 Exocytotic Pathway Liu, C.-C. S., et al. | July 16, 2021 The trafficking of proteins such as aquaporin-2 (AQP2) in the exocytotic pathway requires an active…pthomsonJuly 16, 2021 Read More
Publications of the Week Nephrotoxicity Assessment with Human Kidney Tubuloids using Spherical Nucleic Acid-Based mRNA Nanoflares Wiraja, C., et al. | July 14, 2021 Drug-induced nephrotoxicity represents an important cause of acute kidney injury with associated patient morbidity and…pthomsonJuly 14, 2021 Read More
Publications of the Week Expansion of Tumor-Associated Treg Cells upon Disruption of a CTLA-4-Dependent Feedback Loop Marangoni, F., et al. | July 7, 2021 This week we profile a recent publication in Cell from Dr. Thorsten Mempel's lab at…pthomsonJuly 7, 2021 Read More
Publications of the Week Tick-Over Mediated Complement Activation Is Sufficient to Cause Basal Deposit Formation in Cell-Based Models of Macular Degeneration Chinchilla, B., et al. | July 6, 2021 This week we profile a recent publication in the Journal of Pathology from Dr. Rosario…pthomsonJuly 6, 2021 Read More
Publications of the Week Plasma from Patients with Bacterial Sepsis or Severe COVID-19 Induces Suppressive Myeloid Cell Production from Hematopoietic Progenitors In Vitro Reyes, M., et al. | July 2, 2021 Patients with bacterial sepsis or severe COVID-19 have increased numbers of suppressive myeloid cells in…pthomsonJuly 2, 2021 Read More
Publications of the Week Fatty Acids Activate the Transcriptional Coactivator YAP1 to Promote Liver Fibrosis via p38 Mitogen-Activated Protein Kinase Salloum, S., et al. | July 1, 2021 Patients with simple steatosis (SS) and nonalcoholic steatohepatitis can develop progressive liver fibrosis, which is…pthomsonJuly 1, 2021 Read More
Publications of the Week Microbiota-Derived Acetate Activates Intestinal Innate Immunity via the Tip60 Histone Acetyltransferase Complex Jugder, B.-E., et al. | June 28, 2021 Enteroendocrine cells are rare intestinal cells that respond to microbial metabolites. Dr. Paula Watnick’s laboratory…pthomsonJune 28, 2021 Read More