Publications of the Week Understanding Transcription across Scales: From Base Pairs to Chromosomes Vos, S. M. | March 29, 2021 The influence of genome organization on transcription is central to our understanding of cell type…pthomsonMarch 29, 2021 Read More
Publications of the Week Mucin O-Glycans Suppress Quorum-Sensing Pathways and Genetic Transformation in Streptococcus Mutans Werlang, C. A., et al. | March 26, 2021 Mucus barriers accommodate trillions of microorganisms throughout the human body while preventing pathogenic colonization. In…pthomsonMarch 26, 2021 Read More
Publications of the Week Checkpoint Blockade Toxicities: Insights into Autoimmunity and Treatment Walsh, M. J. and Dougan, M. | March 23, 2021 Checkpoint blockade has transformed not only the way cancers are treated, but also highlighted the…pthomsonMarch 23, 2021 Read More
Publications of the Week Interleukin-6 Produced by Enteric Neurons Regulates the Number and Phenotype of Microbe-Responsive Regulatory T Cells in the Gut Yan, Y., et al. | March 19, 2021 The immune and enteric nervous (ENS) systems monitor the frontier with commensal and pathogenic microbes…pthomsonMarch 19, 2021 Read More
Publications of the Week Barcoded Oligonucleotides Ligated on RNA Amplified for Multiplexed and Parallel in Situ Analyses Liu, S., et al. | March 16, 2021 We present barcoded oligonucleotides ligated on RNA amplified for multiplexed and parallel insitu analyses (BOLORAMIS),…sciencecityMarch 16, 2021 Read More
Publications of the Week Cell Derived Extracellular Matrix-Rich Biomimetic Substrate Supports Podocyte Proliferation, Differentiation and Maintenance of Native Phenotype Satyam, A., et al. | March 15, 2021 Current technologies and available scaffold materials do not support long-term cell viability, differentiation and maintenance…sciencecityMarch 15, 2021 Read More
Publications of the Week Chemokine CCL5 Promotes Robust Optic Nerve Regeneration and Mediates Many of the Effects of CNTF Gene Therapy Xie, L., et al. | March 11, 2021 Ciliary neurotrophic factor (CNTF) is a leading therapeutic candidate for several ocular diseases and induces…sciencecityMarch 11, 2021 Read More
Publications of the Week Increased Stem Cell Proliferation in Atherosclerosis Accelerates Clonal Hematopoiesis Heyde, A., et al. | March 10, 2021 Clonal hematopoiesis, a condition in which individual hematopoietic stem cell clones generate a disproportionate fraction…sciencecityMarch 10, 2021 Read More
Publications of the Week Cryo-EM Structure of an Activated GPCR-G Protein Complex in Lipid Nanodiscs Zhang, M., et al. | March 5, 2021 G-protein-coupled receptors (GPCRs) are the largest superfamily of transmembrane proteins and the targets of over…sciencecityMarch 5, 2021 Read More
Publications of the Week Clinical Implications of Colorectal Cancer Stem Cells in the Age of Single-Cell Omics and Targeted Therapies Frank, M.H., et al. | March 2, 2021 The cancer stem cell (CSC) concept emerged from the recognition of inherent tumor heterogeneity and…sciencecityMarch 2, 2021 Read More