Publications of the Week Delivering Genes across the Blood-Brain Barrier: LY6A, a Novel Cellular Receptor for Aav-PHP.B Capsids Huang, Q., et al. | November 22, 2019 The engineered AAV-PHP.B family of adeno-associated virus efficiently delivers genes throughout the mouse central nervous…sciencecityNovember 22, 2019 Read More
Publications of the Week A New Antibiotic Selectively Kills Gram-Negative Pathogens Imai, Y., et al. | November 21, 2019 The current need for novel antibiotics is especially acute for drug-resistant Gram-negative pathogens. These microorganisms…sciencecityNovember 21, 2019 Read More
Publications of the Week T Lymphocytes and Cytotoxic Astrocyte Blebs Correlate Across Autism Brains DiStasio, M., M., et al. | November 15, 2019 Autism spectrum disorder (ASD) affects 1 in 59 children, yet except for rare genetic causes,…sciencecityNovember 15, 2019 Read More
Publications of the Week Retro-2 Protects Cells from Ricin Toxicity by Inhibiting ASNA1-Mediated Er Targeting and Insertion of Tail-Anchored Proteins Morgens, D., W., et al. | November 13, 2019 The small molecule Retro-2 prevents ricin toxicity through a poorly-defined mechanism of action (MOA), which…sciencecityNovember 13, 2019 Read More
Publications of the Week Inducible Histone K-to-M Mutations Are Dynamic Tools to Probe the Physiological Role of Site-Specific Histone Methylation In Vitro and In Vivo Brumbaugh, J., et al. | November 8, 2019 Development and differentiation are associated with profound changes to histone modifications, yet their in vivo…sciencecityNovember 8, 2019 Read More
Publications of the Week A Generalized HIV Vaccine Design Strategy for Priming of Broadly Neutralizing Antibody Responses Steichen, J., M., et al. | November 7, 2019 Vaccine induction of broadly neutralizing antibodies (bnAbs) to human immunodeficiency virus (HIV) remains a major…sciencecityNovember 7, 2019 Read More
Publications of the Week Genotype-Fitness Maps of EGFR-Mutant Lung Adenocarcinoma Chart the Evolutionary Landscape of Resistance for Combination Therapy Optimization Bolan, P., O., et al. | October 30, 2019 Cancer evolution poses a central obstacle to cure, as resistant clones expand under therapeutic selection…sciencecityOctober 30, 2019 Read More
Publications of the Week Fibroblastic Reticular Cells Enhance T Cell Metabolism and Survival via Epigenetic Remodeling Brown, F., D., et al. | October 28, 2019 Lymph node fibroblastic reticular cells (FRCs) respond to signals from activated T cells by releasing…sciencecityOctober 28, 2019 Read More
Publications of the Week A Rapid Triage Test for Active Pulmonary Tuberculosis in Adult Patients with Persistent Cough Ahmad, R., et al. | October 28, 2019 Tuberculosis remains a global health burden. Ahmad et al. used machine learning to develop an algorithm…sciencecityOctober 28, 2019 Read More
Publications of the Week Cell Swelling, Softening and Invasion in a Three-Dimensional Breast Cancer Model Han, Y., H., et al. | October 24, 2019 Control of the structure and function of three-dimensional multicellular tissues depends critically on the spatial…sciencecityOctober 24, 2019 Read More