Publications of the Week Highly Multiplexed Spatial Transcriptomics in BacteriaSarfatis, A., et al. | February 13, 2025Many bacteria inhabit complex, spatially structured environments and exhibit behaviors not well captured by population…karnottFebruary 13, 2025 Read More
Publications of the Week First-in-Human Phase 1/2 Study (MYCHELANGELO I) of First-in-Class Epigenomic Controller OTX-2002 Targeting MYC Oncogene in Patients With Hepatocellular Carcinoma (HCC) and Other Solid Tumors.Mizrahi, J., et al. | February 11, 2025Background: The c-MYC (MYC) oncogene is a master transcription factor of tumor cell and microenvironment…karnottFebruary 11, 2025 Read More
Publications of the Week ChromoGen: Diffusion Model Predicts Single-Cell Chromatin ConformationsSchuette, G., et al. | February 7, 2025Breakthroughs in high-throughput sequencing and microscopic imaging technologies have revealed that chromatin structures vary considerably…karnottFebruary 7, 2025 Read More
Publications of the Week AI Model Learns Generalized “Language” of Regulatory Genomics, Predicts Cellular StoriesJaved, N., et al. | February 5, 2025A team of investigators from Dana-Farber Cancer Institute, The Broad Institute of MIT and Harvard,…karnottFebruary 5, 2025 Read More
Publications of the Week The Meninges Host a Distinct Compartment of Regulatory T Cells That Preserves Brain HomeostasisMarin-Rodero, M., et al. | February 3, 2025Our understanding of the meningeal immune system has recently burgeoned, particularly regarding how innate and…karnottFebruary 3, 2025 Read More
Publications of the Week Variants and Vaccines Impact Nasal Immunity Over Three Waves of SARS-CoV-2Walsh, J., et al. | January 31, 2025Viral variant and host vaccination status impact infection with severe acute respiratory syndrome coronavirus 2…karnottJanuary 31, 2025 Read More
Publications of the Week Rickettsia parkeri Forms Extensive, Stable Contacts with the Rough Endoplasmic ReticulumAcevedo-Sánchez, Y., et al. | January 29, 2025Upon invasion into the host cell, a subset of bacterial pathogens resides exclusively in the…karnottJanuary 29, 2025 Read More
Publications of the Week Long Somatic DNA-Repeat Expansion Drives Neurodegeneration in Huntington’s DiseaseHandsaker, R., et al. | January 27, 2025In Huntington’s disease (HD), striatal projection neurons (SPNs) degenerate during midlife; the core biological question…karnottJanuary 27, 2025 Read More
Publications of the Week Structural and Functional Analysis of the Nipah Virus Polymerase Complex | January 22, 2025Nipah virus (NiV) is a bat-borne, zoonotic RNA virus that is highly pathogenic in humans.…karnottJanuary 22, 2025 Read More
Publications of the Week Exocyst Stimulates Multiple Steps of Exocytic SNARE Complex Assembly and Vesicle FusionLee, C., et al. | January 20, 2025Exocyst is a large multisubunit tethering complex essential for targeting and fusion of secretory vesicles…karnottJanuary 20, 2025 Read More