Publications of the Week Cultivated Autologous Limbal Epithelial Cell (CALEC) Transplantation for Limbal Tem Cell Deficiency: A Phase I/II Clinical Trial of the First Xenobiotic-Free, Serum-Free, Antibiotic-Free Manufacturing Protocol Developed in the USJurkunas, U., et al. | March 13, 2025We developed a two-stage manufacturing process utilizing cultivated autologous limbal epithelial cells (CALEC), the first…karnottMarch 13, 2025 Read More
Publications of the Week Meta-Analysis of Genome-Wide Associations and Polygenic Risk Prediction for Atrial Fibrillation in More Than 180,000 CasesNature Genetics | March 11, 2025Atrial fibrillation (AF) is the most common heart rhythm abnormality and is a leading cause…karnottMarch 11, 2025 Read More
Publications of the Week Programs, Origins, and Immunomodulatory Functions of Myeloid Cells in GliomaMiller, T., et al. | March 7, 2025Gliomas are incurable malignancies notable for having an immunosuppressive microenvironment with abundant myeloid cells, the…karnottMarch 7, 2025 Read More
Publications of the Week Granzyme K Activates the Entire Complement CascadeDonado, C., et al. | March 5, 2025Granzymes are a family of serine proteases mainly expressed by CD8+ T cells, natural killer…karnottMarch 5, 2025 Read More
Publications of the Week LUC7 Proteins Define Two Major Classes of 5′ Splice Sites in Animals and PlantsKenny, C., et al. | March 3, 2025Mutation or deletion of the U1 snRNP-associated factor LUC7L2 is associated with myeloid neoplasms, and…karnottMarch 3, 2025 Read More
Publications of the Week A Window-of-Opportunity Trial Reveals Mechanisms of Response and Resistance to Navtemadlin in Patients With Recurrent GlioblastomaRendo, V., et al. | February 27, 2025Many glioblastomas express wild-type TP53, which may make them susceptible to pharmacological inhibition of MDM2…karnottFebruary 27, 2025 Read More
Publications of the Week Macrophages Protect Against Sensory Axon Loss in Peripheral NeuropathyHakim, S., et al. | February 24, 2025Peripheral neuropathy is a common complication of type 2 diabetes, which is strongly associated with…karnottFebruary 24, 2025 Read More
Publications of the Week Mussel-Inspired Cross-Linking Mechanisms Enhance Gelation and Adhesion of Multifunctional Mucin-Derived HydrogelsDegen, G., et al. | February 20, 2025The layers of mucus coating vulnerable surfaces in the body are composed of lubricious, bioactive…karnottFebruary 20, 2025 Read More
Publications of the Week GUK1 Activation Is a Metabolic Liability in Lung CancerSchneider, J., et al. | February 17, 2025Little is known about metabolic vulnerabilities in oncogene-driven lung cancer. Here, we perform a phosphoproteomic…karnottFebruary 17, 2025 Read More
Publications of the Week SKI Complex Loss Renders 9p21.3-Deleted or MSI-H Cancers Dependent on PELOBorck, J., et al. | February 14, 2025Cancer genome alterations often lead to vulnerabilities that can be used to selectively target cancer…karnottFebruary 14, 2025 Read More