Publications of the Week CDK5-Cyclin B1 Regulates Mitotic FidelityZheng, X., et al. | September 12, 2024CDK1 has been known to be the sole cyclin-dependent kinase (CDK) partner of cyclin B1…karnottSeptember 12, 2024 Read More
Publications of the Week Tumor Editing Suppresses Innate and Adaptive Antitumor Immunity and Is Reversed by Inhibiting DNA MethylationZhang, Y., et al. | September 11, 2024Cancer cells edit gene expression to evade immunosurveillance. However, genome-wide studies of gene editing during…karnottSeptember 11, 2024 Read More
Publications of the Week RAD21 Promotes Oncogenesis and Lethal Progression of Prostate CancerSu, X., et al. | September 4, 2024Chromosome arm 8q is the most frequently gained chromosome arm in aneuploid prostate cancer and…karnottSeptember 4, 2024 Read More
Publications of the Week Viral DNA Polymerase Structures Reveal Mechanisms of Antiviral Drug ResistanceShankar, S., et al. | September 2, 2024DNA polymerases are important drug targets, and many structural studies have captured them in distinct…karnottSeptember 2, 2024 Read More
Publications of the Week Donepezil Nanoemulsion Induces a Torpor-like State with Reduced Toxicity in Nonhibernating Xenopus laevis TadpolesOliver, M., et al. | August 29, 2024Achieving a reversible decrease of metabolism and other physiological processes in the whole organism, as…karnottAugust 29, 2024 Read More
Publications of the Week Cell-Selective Proteomics Reveal Novel Effectors Secreted by an Obligate Intracellular Bacterial PathogenSanderlin, A., et al. | August 26, 2024Pathogenic bacteria secrete protein effectors to hijack host machinery and remodel their infectious niche. Rickettsia…karnottAugust 26, 2024 Read More
Publications of the Week Parsing Digital or Analog TCR Performance Through Piconewton ForcesAkitsu, A., et al. | August 23, 2024αβ T cell receptors (TCRs) principally recognize aberrant peptides bound to major histocompatibility complex molecules…karnottAugust 23, 2024 Read More
Publications of the Week The Choroid Plexus Synergizes with Immune Cells During NeuroinflammationXu, H., et al. | August 21, 2024The choroid plexus (ChP) is a vital brain barrier and source of cerebrospinal fluid (CSF).…karnottAugust 21, 2024 Read More
Publications of the Week Enhancing siRNA Efficacy In Vivo with Extended Nucleic Acid BackbonesYamada, K., et al. | August 16, 2024Therapeutic small interfering RNA (siRNA) requires sugar and backbone modifications to inhibit nuclease degradation. However,…karnottAugust 16, 2024 Read More
Publications of the Week Loss of Kmt2c or Kmt2d Drives Brain Metastasis via KDM6A-Dependent Upregulation of MMP3Seehawer, M., et al. | August 12, 2024KMT2C and KMT2D, encoding histone H3 lysine 4 methyltransferases, are among the most commonly mutated…karnottAugust 12, 2024 Read More