Publications of the Week Polygenic Modifiers Impact Penetrance and Expressivity in Telomere Biology Disorders Poeschla, M., et al. | June 5, 2025 BACKGROUND. Telomere biology disorders (TBDs) exhibit incomplete penetrance and variable expressivity, even among individuals harboring…karnottJune 5, 2025 Read More
Publications of the Week Evolution-Guided Protein Design of IscB for Persistent Epigenome Editing In Vivo Kannan, S., et al. | June 3, 2025 Naturally existing enzymes have been adapted for a variety of molecular technologies, with enhancements or…karnottJune 3, 2025 Read More
Publications of the Week Large-Scale Combination Screens Reveal Small-Molecule Sensitization of Antibiotic-Resistant Gram-Negative ESKAPE Pathogens Tse, M., et al. | June 2, 2025 There is an unmet need for new antibiotic therapies effective against the multidrug-resistant, bacterial pathogens.…karnottJune 2, 2025 Read More
Publications of the Week U1 SnRNP Regulates Alternative Promoter Activity by Inhibiting Premature Polyadenylation Kim, G., et al. | May 29, 2025 Emerging evidence indicates that splicing factors mediate the close link between transcription and splicing. However,…sciencecityMay 29, 2025 Read More
Publications of the Week Single-Cell Transcriptomic Characterization of Microscopic Colitis Halvorsen, S., et al. | May 27, 2025 Microscopic colitis (MC) is a chronic inflammatory disease of the large intestine and a common…sciencecityMay 27, 2025 Read More
Publications of the Week Single-Cell Transcriptomics and Lineage Tracing Unveil Parallels in Lymphatic Muscle and Venous Smooth Muscle Development, Identity, and Function Arroyo-Ataz, G., et al. | May 23, 2025 Lymphatic muscle cells (LMCs) are indispensable for lymphatic vessel contraction, and their aberrant recruitment or…sciencecityMay 23, 2025 Read More
Publications of the Week Mitochondrial Transfer in Endothelial Cells and Vascular Health Im, G.B. and Melero-Martin, J.M. | May 21, 2025 Mitochondria play a vital role in cellular energy metabolism and vascular health, with their function…sciencecityMay 21, 2025 Read More
Publications of the Week Differential Aortic Aneurysm Formation Provoked by Chemogenetic Oxidative Stress Das, A., et al. | May 15, 2025 Aortic aneurysms are potentially fatal focal enlargements of the aortic lumen; the disease burden is…karnottMay 15, 2025 Read More
Publications of the Week LINE-1 ORF1p Mimics Viral Innate Immune Evasion Mechanisms in Pancreatic Ductal Adenocarcinoma You, E., et al. | May 14, 2025 Repeat element viral mimicry is a common feature in pancreatic ductal adenocarcinoma (PDAC) that requires…karnottMay 14, 2025 Read More
Publications of the Week Signaling and Transcriptional Dynamics Underlying Early Adaptation to Oncogenic BRAF Inhibition Flower, C., et al. | May 12, 2025 A major contributor to poor sensitivity to anti-cancer kinase inhibitor therapy is drug-induced cellular adaptation,…karnottMay 12, 2025 Read More