Publications of the Week Integrator Loss Leads to dsRNA Formation That Triggers the Integrated Stress Response Baluapuri, A., et al. | May 8, 2025 Integrator (INT) is a metazoan-specific complex that targets promoter-proximally paused RNA polymerase II (RNAPII) for…karnottMay 8, 2025 Read More
Publications of the Week RNA-Binding Proteins and glycoRNAs Form Domains on the Cell Surface for Cell-Penetrating Peptide Entry Perr, J., et al. | May 6, 2025 The composition and organization of the cell surface determine how cells interact with their environment.…karnottMay 6, 2025 Read More
Publications of the Week Model-Guided Design of microRNA-Based Gene Circuits Supports Precise Dosage of Transgenic Cargoes Into Diverse Primary Cells Love, K., et al. | May 2, 2025 In a therapeutic context, supraphysiological expression of transgenes can compromise engineered phenotypes and lead to…karnottMay 2, 2025 Read More
Publications of the Week Factors Associated With Disease Progression After Discontinuation of Immune Checkpoint Inhibitors for Immune-Related Toxicity in Patients With Advanced Non–Small Cell Lung Cancer Pecci, F., et al. | April 30, 2025 Among patients with advanced non–small cell lung cancer (NSCLC) who discontinue immune checkpoint inhibitors (ICI)…karnottApril 30, 2025 Read More
Publications of the Week Epigenomic Regulation of Stemness Contributes to the Low Immunogenicity of the Most Mutated Human Cancer Oka, T., et al. | April 28, 2025 Despite harboring the highest tumor mutational burden of all cancers, basal cell carcinoma (BCC) has…karnottApril 28, 2025 Read More
Publications of the Week Rules of Engagement for Condensins and Cohesins Guide Mitotic Chromosome Formation Samejima, K., et al. | April 23, 2025 Structural maintenance of chromosomes (SMC) protein complexes, which include cohesin and condensin, play crucial roles…karnottApril 23, 2025 Read More
Publications of the Week Transcription Factor Networks Disproportionately Enrich for Heritability of Blood Cell Phenotypes Martin-Rufino, J., et al. | April 21, 2025 This week, we profile a recent publication in Science by Dr. Vijay Sankaran’s lab (pictured,…karnottApril 21, 2025 Read More
Publications of the Week Immune Checkpoint TIM-3 Regulates Microglia and Alzheimer’s Disease Kimura, K., et al. | April 17, 2025 Microglia are the resident immune cells in the brain and have pivotal roles in neurodevelopment…karnottApril 17, 2025 Read More
Publications of the Week Lysine Vitcylation Is a Vitamin C-Derived Protein Modification That Enhances STAT1-Mediated Immune Response He, X., et al. | April 15, 2025 Vitamin C (vitC) is essential for health and shows promise in treating diseases like cancer,…karnottApril 15, 2025 Read More
Publications of the Week Molecular Basis for Shifted Receptor Recognition by an Encephalitic Arbovirus Fan, X., et al. | April 11, 2025 Western equine encephalitis virus (WEEV) is an arbovirus that historically caused large outbreaks of encephalitis…karnottApril 11, 2025 Read More