Publications of the Week Transcriptional Suppression of Sphingolipid Catabolism Controls Pathogen Resistance in C. elegansNasrallah, M., et al. | November 7, 2023Sphingolipids are required for diverse biological functions and are degraded by specific catabolic enzymes. However,…sciencecityNovember 7, 2023 Read More
Publications of the Week The Sporadic Early-onset Alzheimer’s Disease Signature Of Atrophy: Preliminary Findings From The Longitudinal Early-onset Alzheimer’s Disease Study (LEADS) CohortTouroutoglou, A., et al. | November 1, 2023Sporadic early-onset Alzheimer's disease (EOAD; symptomatic onset <65 years) is a rare and understudied but…sciencecityNovember 1, 2023 Read More
Publications of the Week Microglia and Complement Mediate Early Corticostriatal Synapse Loss and Cognitive Dysfunction in Huntington’s DiseaseWilton, D., et al. | October 30, 2023Huntington’s disease (HD) is a devastating monogenic neurodegenerative disease characterized by early, selective pathology in…sciencecityOctober 30, 2023 Read More
Publications of the Week Carcinogen Exposure Enhances Cancer Immunogenicity by Blocking the Development of an Immunosuppressive Tumor MicroenvironmentHuang, M., et al. | October 27, 2023Carcinogen exposure is strongly associated with enhanced cancer immunogenicity. Increased tumor mutational burden and resulting…sciencecityOctober 27, 2023 Read More
Publications of the Week Clinical Trial Links Oncolytic Immunoactivation to Survival in GlioblastomaLing, A., et al. | October 25, 2023Immunotherapy failures can result from the highly suppressive tumour microenvironment that characterizes aggressive forms of…sciencecityOctober 25, 2023 Read More
Publications of the Week Allelic Chromatin Structure Precedes Imprinted Expression of Kcnk9 During NeurogenesisLoftus, D., et al. | October 23, 2023Differences in chromatin state inherited from the parental gametes influence the regulation of maternal and…sciencecityOctober 23, 2023 Read More
Publications of the Week A Mouse Model with High Clonal Barcode Diversity for Joint Lineage, Transcriptomic, and Epigenomic Profiling in Single CellsLi, L., et al. | October 20, 2023Cellular lineage histories and their molecular states encode fundamental principles of tissue development and homeostasis.…sciencecityOctober 20, 2023 Read More
Publications of the Week A Disordered Region Controls cBAF Activity via Condensation and Partner RecruitmentPatil, A., et al. | October 18, 2023Intrinsically disordered regions (IDRs) represent a large percentage of overall nuclear protein content. The prevailing…sciencecityOctober 18, 2023 Read More
Publications of the Week Targeting PGLYRP1 Promotes Antitumor Immunity While Inhibiting Autoimmune NeuroinflammationSchnell, A., et al. | October 16, 2023Co-inhibitory and checkpoint molecules suppress T cell function in the tumor microenvironment, thereby rendering T…sciencecityOctober 16, 2023 Read More
Publications of the Week Cell-Type-Specific Regulation of APOE and CLU Levels in Human Neurons by the Alzheimer’s Disease Risk Gene SORL1Lee, H., et al. | October 13, 2023SORL1 is implicated in the pathogenesis of Alzheimer’s disease (AD) through genetic studies. To interrogate…sciencecityOctober 13, 2023 Read More