Publications of the Week Distinct Negative Elongation Factor Conformations Regulate RNA Polymerase II Promoter-Proximal PausingSu, B., et al. | March 1, 2024Metazoan gene expression regulation involves pausing of RNA polymerase (Pol II) in the promoter-proximal region…karnottMarch 1, 2024 Read More
Publications of the Week Integrative Analyses of Tumor and Peripheral Biomarkers in the Treatment of Advanced Renal Cell CarcinomaChoueiri, T., et al. | February 28, 2024The phase III JAVELIN Renal 101 trial demonstrated prolonged progression-free survival (PFS) in patients (N = 886)…karnottFebruary 28, 2024 Read More
Publications of the Week Genetic Architecture and Biology of Youth-Onset Type 2 DiabetesKwak, S., et al. | February 26, 2024The prevalence of youth-onset type 2 diabetes (T2D) and childhood obesity has been rising steadily1,…karnottFebruary 26, 2024 Read More
Publications of the Week Capivasertib Combines with Docetaxel to Enhance Anti-Tumour Activity Through Inhibition of AKT-Mediated Survival Mechanisms in Prostate CancerEberlein, C., et al. | February 23, 2024Combining docetaxel and capivasertib had increased activity in PTEN null and WT prostate tumour models…karnottFebruary 23, 2024 Read More
Publications of the Week Genome-Wide Association Study Identifies Human Genetic Variants Associated with Fatal Outcome from Lassa FeverKotliar, D., et al. | February 19, 2024Infection with Lassa virus (LASV) can cause Lassa fever, a haemorrhagic illness with an estimated…karnottFebruary 19, 2024 Read More
Publications of the Week Enhancing Cancer Immunotherapy via Inhibition of Soluble Epoxide HydrolaseKelly, A., et al. | February 13, 2024While immunotherapy is a front-line cancer treatment, unresolved chronic inflammation and toxicities often limit its…karnottFebruary 13, 2024 Read More
Publications of the Week Direct Reprogramming of Non-limb Fibroblasts to Cells with Properties of Limb ProgenitorsAtsuta, Y., et al. | February 12, 2024The early limb bud consists of mesenchymal limb progenitors derived from the lateral plate mesoderm…karnottFebruary 12, 2024 Read More
Publications of the Week Cryptic Splicing of Stathmin-2 and UNC13A mRNAs Is a Pathological Hallmark of TDP-43-Associated Alzheimer’s DiseaseAlmeida Quadros, A., et al. | February 9, 2024Nuclear clearance and cytoplasmic accumulations of the RNA-binding protein TDP-43 are pathological hallmarks in almost…karnottFebruary 9, 2024 Read More
Publications of the Week Improved Immunostaining of Nanostructures and Cells in Human Brain Specimens Through Expansion-Mediated Protein DecrowdingValdes, P., et al. | February 7, 2024Proteins are densely packed in cells and tissues, where they form complex nanostructures. Expansion microscopy…karnottFebruary 7, 2024 Read More
Publications of the Week CAG Repeat Expansions Create Splicing Acceptor Sites and Produce Aberrant Repeat-Containing RNAsAnderson, R., et al. | February 5, 2024Expansions of CAG trinucleotide repeats cause several rare neurodegenerative diseases. The disease-causing repeats are translated…karnottFebruary 5, 2024 Read More