Publications of the Week Association of Caffeine and Related Analytes with Resistance to Parkinson’s Disease among LRRK2 Mutation Carriers: A Metabolomic StudyCrotty, G. F., et al. | October 12, 2020This study observed that caffeine and its related analytes were lower in individuals with Parkinson's…eabramovichOctober 12, 2020 Read More
Publications of the Week Targeting the HIF2–VEGF Axis in Renal Cell CarcinomaChoueiri, T.K., & Kaelin Jr., W.G. | October 9, 2020Insights into the role of the tumor suppressor pVHL in oxygen sensing motivated the testing…eabramovichOctober 9, 2020 Read More
Publications of the Week Divergent Roles of PI3K Isoforms in PTEN-Deficient GlioblastomasXie, S., et al. | October 8, 2020Loss of PTEN, the negative regulator of PI3K activity, is frequent in glioblastomas (GBMs). However,…eabramovichOctober 8, 2020 Read More
Publications of the Week pH-Gated Succinate Secretion Regulates Muscle Remodeling in Response to ExerciseReddy, A., et al. | October 1, 2020The authors discovered that exercising muscle selectively releases the mitochondrial metabolite succinate. Once released, succinate…eabramovichOctober 1, 2020 Read More
Publications of the Week HDAC6 Mediates an Aggresome-Like Mechanism for NLRP3 and Pyrin Inflammasome ActivationMagupalli, V.G., et al. | September 28, 2020Canonical inflammasomes are multicomponent protein complexes that play key roles in immune surveillance of infections…eabramovichSeptember 28, 2020 Read More
Publications of the Week A Regulatory T Cell Notch4–GDF15 Axis Licenses Tissue Inflammation in AsthmaHarb, H., et al. | September 24, 2020This study provides a comprehensive framework for understanding inflammation in asthma. The authors identified a…eabramovichSeptember 24, 2020 Read More
Publications of the Week Antibiotic Susceptibility Signatures Identify Potential Antimicrobial Targets in the Acinetobacter baumannii Cell EnvelopeGeisinger, E., et al. | September 23, 2020A unique, protective cell envelope contributes to the broad drug resistance of the nosocomial pathogen Acinetobacter…eabramovichSeptember 23, 2020 Read More
Publications of the Week CSF1R Inhibition by a Small-Molecule Inhibitor Is Not Microglia Specific; Affecting Hematopoiesis and the Function of MacrophagesLei, F., et al. | September 16, 2020Colony-stimulating factor 1 receptor (CSF1R) inhibition has been extensively adopted by many laboratories for the…eabramovichSeptember 16, 2020 Read More
Publications of the Week Cell-Based Artificial APC Resistant to Lentiviral Transduction for Efficient Generation of CAR-T Cells from Various Cell SourcesSchmidts, A., et al. | September 14, 2020Adoptive cell therapy with chimeric antigen receptor T cells (CAR-T) has become a standard treatment…eabramovichSeptember 14, 2020 Read More
Publications of the Week STING Cyclic Dinucleotide Sensing Originated in BacteriaMorehouse, B.R., et al. | September 11, 2020Stimulator of interferon genes (STING) is a receptor in human cells that senses foreign cyclic…eabramovichSeptember 11, 2020 Read More