Publications of the Week Developmental Dynamics of RNA Translation in the Human Brain Duffy, E. E., et al | September 30, 2022 The precise regulation of gene expression is fundamental to neurodevelopment, plasticity and cognitive function. Although…pthomsonSeptember 30, 2022 Read More
Publications of the Week Organoid-on-a-Chip Model of Human ARPKD Reveals Mechanosensing Pathomechanisms for Drug Discovery Hiratsuka, K., & Miyoshi, T., et al. | September 22, 2022 Organoids serve as a novel tool for disease modeling in three-dimensional multicellular contexts. Static organoids,…pthomsonSeptember 22, 2022 Read More
Publications of the Week High-Performance Multiplex Drug-Gated CAR Circuits Li, H.S., et al. | September 21, 2022 Chimeric antigen receptor (CAR) T cells can revolutionize cancer medicine. However, overactivation, lack of tumor-specific…sciencecitySeptember 21, 2022 Read More
Publications of the Week A Bacterial Pan-Genome Makes Gene Essentiality Strain-Dependent and Evolvable Rosconi, F. et al. | September 19, 2022 Many bacterial species are represented by a pan-genome, whose genetic repertoire far outstrips that of…sciencecitySeptember 19, 2022 Read More
Publications of the Week Targeting Innate Immunity-Driven Inflammation in CKD and Cardiovascular Disease Speer, T., et al. | September 14, 2022 Mortality among patients with chronic kidney disease (CKD) is largely a consequence of cardiovascular disease…sciencecitySeptember 14, 2022 Read More
Publications of the Week Dissecting the Role of the Human Microbiome in COVID-19 via Metagenome-Assembled Genomes Ke, S., et al. | September 12, 2022 Coronavirus disease 2019 (COVID-19), primarily a respiratory disease caused by infection with Severe Acute Respiratory…sciencecitySeptember 12, 2022 Read More
Publications of the Week Cell Type-Specific Inference of Differential Expression in Spatial Transcriptomics Cable, D.M., et al. | September 9, 2022 A central problem in spatial transcriptomics is detecting differentially expressed (DE) genes within cell types…sciencecitySeptember 9, 2022 Read More
Publications of the Week PD-L1 and PD-1 Expression in Pediatric Central Nervous System Germ Cell Tumors Woods, J.K., et al. | September 7, 2022 Central nervous system (CNS) germ cell tumors (GCTs) represent 2-3% of all primary CNS tumors.…sciencecitySeptember 7, 2022 Read More
Publications of the Week Regulation of Neuroendocrine Plasticity by the RNA-Binding Protein ZFP36L1 Chen, H.-Y., et al. | September 2, 2022 Some small cell lung cancers (SCLCs) are highly sensitive to inhibitors of the histone demethylase…pthomsonSeptember 2, 2022 Read More
Publications of the Week Elucidating the Path to Plasmodium Prolyl-tRNA Synthetase Inhibitors That Overcome Halofuginone Resistance Tye, M. A., et al. | September 1, 2022 The development of next-generation antimalarials that are efficacious against the human liver and asexual blood…pthomsonSeptember 1, 2022 Read More