Publications of the Week Extracellular Matrix Plasticity as a Driver of Cell SpreadingGrolman, J.M., et al. | October 23, 2020In many biomaterial systems, plastic deformation of extracellular matrix, degradation, or relaxation of stress are…eabramovichOctober 23, 2020 Read More
Publications of the Week Absence of Survival and Motor Deficits in 500 Repeat C9ORF72 BAC MiceMordes, D.A., et al. | October 22, 2020A hexanucleotide repeat expansion at C9ORF72 is the most common genetic cause of amyotrophic lateral…eabramovichOctober 22, 2020 Read More
Publications of the Week Parallel Single-Cell RNA-Seq and Genetic Recording Reveals Lineage Decisions in Developing Embryoid BodiesKim, I.S., et al. | October 21, 2020Early developmental specification can be modeled by differentiating embryonic stem cells (ESCs) to embryoid bodies…eabramovichOctober 21, 2020 Read More
Publications of the Week A Stearoyl-CoA Desaturase Inhibitor Prevents Multiple Parkinson’s Disease-Phenotypes in α-Synuclein MiceNuber, S., et al. | October 14, 2020The α-synuclein protein accumulates in Parkinson’s disease and other synucleinopathies. Growing evidence suggests that lipid-rich…eabramovichOctober 14, 2020 Read More
Publications of the Week Association of Caffeine and Related Analytes with Resistance to Parkinson’s Disease among LRRK2 Mutation Carriers: A Metabolomic StudyCrotty, G. F., et al. | October 12, 2020This study observed that caffeine and its related analytes were lower in individuals with Parkinson's…eabramovichOctober 12, 2020 Read More
Publications of the Week Targeting the HIF2–VEGF Axis in Renal Cell CarcinomaChoueiri, T.K., & Kaelin Jr., W.G. | October 9, 2020Insights into the role of the tumor suppressor pVHL in oxygen sensing motivated the testing…eabramovichOctober 9, 2020 Read More
Publications of the Week Divergent Roles of PI3K Isoforms in PTEN-Deficient GlioblastomasXie, S., et al. | October 8, 2020Loss of PTEN, the negative regulator of PI3K activity, is frequent in glioblastomas (GBMs). However,…eabramovichOctober 8, 2020 Read More
Publications of the Week pH-Gated Succinate Secretion Regulates Muscle Remodeling in Response to ExerciseReddy, A., et al. | October 1, 2020The authors discovered that exercising muscle selectively releases the mitochondrial metabolite succinate. Once released, succinate…eabramovichOctober 1, 2020 Read More
Publications of the Week HDAC6 Mediates an Aggresome-Like Mechanism for NLRP3 and Pyrin Inflammasome ActivationMagupalli, V.G., et al. | September 28, 2020Canonical inflammasomes are multicomponent protein complexes that play key roles in immune surveillance of infections…eabramovichSeptember 28, 2020 Read More
Publications of the Week A Regulatory T Cell Notch4–GDF15 Axis Licenses Tissue Inflammation in AsthmaHarb, H., et al. | September 24, 2020This study provides a comprehensive framework for understanding inflammation in asthma. The authors identified a…eabramovichSeptember 24, 2020 Read More