Publications of the Week Graded BMP Signaling Within Intestinal Crypt Architecture Directs Self-Organization of the Wnt-Secreting Stem Cell Niche Kraiczy, J., et al. | April 7, 2023 Signals from the surrounding niche drive proliferation and suppress differentiation of intestinal stem cells (ISCs)…pthomsonApril 7, 2023 Read More
Publications of the Week Structural and Functional Properties of mSWI/SNF Chromatin Remodeling Complexes Revealed through Single-Cell Perturbation Screens Otto, J. E., et al. | April 7, 2023 The mammalian SWI/SNF (mSWI/SNF or BAF) family of chromatin remodeling complexes play critical roles in regulating DNA…pthomsonApril 7, 2023 Read More
Publications of the Week Assessing the Generation of Tissue Resident Memory T Cells by Vaccines Rotrosen, E., et al. | March 31, 2023 Vaccines have been a hugely successful public health intervention, virtually eliminating many once common diseases…pthomsonMarch 31, 2023 Read More
Publications of the Week Lactate Regulates Cell Cycle by Remodeling the Anaphase Promoting Complex Liu, W., et al. | March 31, 2023 Lactate is abundant in rapidly dividing cells due to the requirement for elevated glucose catabolism…pthomsonMarch 31, 2023 Read More
Publications of the Week Potent Acyl-CoA Synthetase 10 inhibitors Kill Plasmodium falciparum by Disrupting Triglyceride Formation Bopp, S., et al. | March 23, 2023 Identifying how small molecules act to kill malaria parasites can lead to new “chemically validated”…pthomsonMarch 23, 2023 Read More
Publications of the Week Smooth Muscle Contributes to the Development and Function of a Layered Intestinal Stem Cell Niche McCarthy, N., et al. | March 22, 2023 Wnt and Rspondin (RSPO) signaling drives proliferation, and bone morphogenetic protein inhibitors (BMPi) impede differentiation,…pthomsonMarch 22, 2023 Read More
Publications of the Week The Conserved Histone Chaperone Spt6 Is Strongly Required for DNA Replication and Genome Stability Miller, C. L. W., et al. | March 16, 2023 Histone chaperones are an important class of proteins that regulate chromatin accessibility for DNA-templated processes.…pthomsonMarch 16, 2023 Read More
Publications of the Week Temporal Single-Cell Atlas of Non-Neuronal Retinal Cells Reveals Dynamic, Coordinated Multicellular Responses to Central Nervous System Injury Benhar, I., et al. | March 15, 2023 Non-neuronal cells are key to the complex cellular interplay that follows central nervous system insult.…pthomsonMarch 15, 2023 Read More
Publications of the Week Multiplexed Analysis of EV Reveals Specific Biomarker Composition with Diagnostic Impact Spitzberg, J. D., et al. | March 10, 2023 Exosomes and extracellular vesicles (EV) are increasingly being explored as circulating biomarkers, but their heterogenous…pthomsonMarch 10, 2023 Read More
Publications of the Week IFNγ Is a Central Node of Cancer Immune Equilibrium Walsh, M. J., et al. | March 9, 2023 Tumors in immune equilibrium are held in balance between outgrowth and destruction by the immune…pthomsonMarch 9, 2023 Read More