Publications of the Week Shigella flexneri Disruption of Cellular Tension Promotes Intercellular SpreadDuncan-Lowey, J.K., et al. | December 2, 2020The findings in this publication demonstrate that the gram-negative intracellular bacterial pathogen Shigella flexneri, which…eabramovichDecember 2, 2020 Read More
Publications of the Week Endogenous Antisense RNA Curbs CD39 Expression in Crohn’s DiseaseHarshe, R.P., et al. | November 27, 2020CD39 is an ectonucleotidase that initiates conversion of extracellular nucleotides into immunosuppressive adenosine. CD39 is…eabramovichNovember 27, 2020 Read More
Publications of the Week Actionable Cytopathogenic Host Responses of Human Alveolar Type 2 Cells to SARS-CoV-2Hekman, R.M., et al. | November 24, 2020The authors investigated the pathways hijacked by the SARS-CoV-2 cells in human alveolar cells during…eabramovichNovember 24, 2020 Read More
Publications of the Week Rev7 Loss Alters Cisplatin Response and Increases Drug Efficacy in Chemotherapy-Resistant Lung CancerVassel, F.M., et al. | November 20, 2020Mutagenic translesion synthesis (TLS) allows cells to increase their survival after DNA damage by bypassing…eabramovichNovember 20, 2020 Read More
Publications of the Week Comprehensive Characterization of Amino Acid Positions in Protein Structures Reveals Molecular Effect of Missense VariantsIqbal, S., et al. | November 13, 2020Recent large-scale sequencing efforts have enabled the detection of millions of missense variants. Elucidating their…eabramovichNovember 13, 2020 Read More
Publications of the Week Chromatin Potential Identified by Shared Single-Cell Profiling of RNA and ChromatinMa, S., et al. | November 11, 2020Cell differentiation and function are regulated across multiple layers of gene regulation, including modulation of…eabramovichNovember 11, 2020 Read More
Publications of the Week Intestinal Organoid/Enteroid-Based Models for CryptosporidiumBhalchandra, S., et al. | November 9, 2020Cryptosporidium is a leading cause of diarrhea and death in young children and untreated AIDS patients…eabramovichNovember 9, 2020 Read More
Publications of the Week Cell Type-Specific Lipid Storage Changes in Parkinson’s Disease Patient Brains Are Recapitulated by Experimental Glycolipid DisturbanceBrekk, O.R., et al. | November 5, 2020This study identified a unique lipid signature in human post-mortem Parkinson’s disease brain, wherein lipids…eabramovichNovember 5, 2020 Read More
Publications of the Week Modulating Androgen Receptor-Driven Transcription in Prostate Cancer with Selective CDK9 InhibitorsRichters, A., et al. | November 2, 2020In pursuit of mechanistically novel modulators of androgen receptor, the authors have discovered a potent,…eabramovichNovember 2, 2020 Read More
Publications of the Week GATA6 Mutations in hiPSCs Inform Mechanisms for Maldevelopment of the Heart, Pancreas, and DiaphragmSharma, A., et al. | October 29, 2020In collaboration with the NIH’s Pediatric Cardiac Genomics Consortium, the authors sequenced thousands of children…eabramovichOctober 29, 2020 Read More