Publications of the Week Longitudinal Single-Cell Imaging of Engineered Strains with Stimulated Raman Scattering to Characterize Heterogeneity in Fatty Acid Production Tague, N., et al. | June 16, 2023 Understanding metabolic heterogeneity is critical for optimizing microbial production of valuable chemicals, but requires tools…pthomsonJune 16, 2023 Read More
Publications of the Week Thyroid Cancers Exhibit Oncogene-Enhanced Macropinocytosis That Is Restrained by IGF1R and Promotes Albumin-Drug-Conjugate Response Hu, H., et al. | June 14, 2023 Oncogene-driven macropinocytosis fuels nutrient scavenging in some cancer types, yet whether this occurs in thyroid…pthomsonJune 14, 2023 Read More
Publications of the Week Epigenetic Suppression of PGC1α (PPARGC1A) Causes Collateral Sensitivity to HMGCR-Inhibitors Within BRAF-Treatment Resistant Melanomas Liang, J., et al. | June 8, 2023 While targeted treatment against BRAF(V600E) improve survival for melanoma patients, many will see their cancer…pthomsonJune 8, 2023 Read More
Publications of the Week Distinct Longevity Mechanisms Across and Within Species and Their Association with Aging Tyshkovskiy, A., et al. | June 8, 2023 Lifespan varies within and across species, but the general principles of its control remain unclear.…pthomsonJune 8, 2023 Read More
Publications of the Week Irisin Acts through Its Integrin Receptor in a Two-Step Process Involving Extracellular Hsp90α A, M., et al. | June 2, 2023 Exercise benefits the human body in many ways. Irisin is secreted by muscle, increased with…pthomsonJune 2, 2023 Read More
Publications of the Week HLA Class I Signal Peptide Polymorphism Determines the Level of CD94/NKG2–HLA-E-Mediated Regulation of Effector Cell Responses Lin, Z., et al. | June 2, 2023 Human leukocyte antigen (HLA)-E binds epitopes derived from HLA-A, HLA-B, HLA-C and HLA-G signal peptides…pthomsonJune 2, 2023 Read More
Publications of the Week Protective Renalase-Deficiency in Beta Cells Shapes Immune Metabolism and Function in Autoimmune Diabetes Bode, K., et al. | May 25, 2023 Type 1 diabetes (T1D) is caused by the immune-mediated loss of pancreatic beta cells that…pthomsonMay 25, 2023 Read More
Publications of the Week Dynamic BH3 Profiling Identifies Pro-Apoptotic Drug Combinations for the Treatment of Malignant Pleural Mesothelioma Potter, D. S., et al. | May 24, 2023 Malignant pleural mesothelioma (MPM) has relatively ineffective first/second-line therapy for advanced disease and only 18%…pthomsonMay 24, 2023 Read More
Publications of the Week Atrophy in Behavioral Variant Frontotemporal Dementia Spans Multiple Large-Scale Prefrontal and Temporal Networks Eldaief, M. C., et al. | May 19, 2023 The identification of a neurodegenerative disorder’s distributed pattern of atrophy—or atrophy “signature”— can lend insights…pthomsonMay 19, 2023 Read More
Publications of the Week ERα-Associated Translocations Underlie Oncogene Amplifications in Breast Cancer Lee, J., et al. | May 18, 2023 Focal copy-number amplification is an oncogenic event. Although recent studies have revealed the complex structure1,2,3 and…pthomsonMay 18, 2023 Read More