Publications of the Week

Notch signaling relies on ligand-induced proteolysis of the transmembrane receptor Notch to liberate a nuclear…

Endotoxin—bacterial lipopolysaccharide (LPS)—is a driver of lethal infection sepsis through excessive activation of innate immune…

Epigenetic lesions that disrupt regulatory elements represent potential cancer drivers. However, we lack experimental models…

The oral microbiome is critical to human health and disease, yet the role that host…

Cancer-associated mesothelial cells (CAMCs) in the tumor microenvironment are thought to promote growth and immune…

Anaplastic lymphoma kinase (ALK)-rearranged non-small cell lung cancer (NSCLC) is treated with ALK tyrosine kinase…

Identification of individuals at highest risk of coronary artery disease (CAD)—ideally before onset—remains an important…

Importance  It remains unclear why lesions in some locations cause epilepsy while others do not. Identifying…

The cardinal classes are a useful simplification of cortical interneuron diversity, but such broad subgroupings…

Transmission and secretion of signals via the choroid plexus (ChP) brain barrier can modulate brain…