Publications of the Week Actionable Cytopathogenic Host Responses of Human Alveolar Type 2 Cells to SARS-CoV-2 Hekman, R.M., et al. | November 24, 2020 The authors investigated the pathways hijacked by the SARS-CoV-2 cells in human alveolar cells during…eabramovichNovember 24, 2020 Read More
Publications of the Week Rev7 Loss Alters Cisplatin Response and Increases Drug Efficacy in Chemotherapy-Resistant Lung Cancer Vassel, F.M., et al. | November 20, 2020 Mutagenic translesion synthesis (TLS) allows cells to increase their survival after DNA damage by bypassing…eabramovichNovember 20, 2020 Read More
Publications of the Week Comprehensive Characterization of Amino Acid Positions in Protein Structures Reveals Molecular Effect of Missense Variants Iqbal, S., et al. | November 13, 2020 Recent large-scale sequencing efforts have enabled the detection of millions of missense variants. Elucidating their…eabramovichNovember 13, 2020 Read More
Publications of the Week Chromatin Potential Identified by Shared Single-Cell Profiling of RNA and Chromatin Ma, S., et al. | November 11, 2020 Cell differentiation and function are regulated across multiple layers of gene regulation, including modulation of…eabramovichNovember 11, 2020 Read More
Publications of the Week Intestinal Organoid/Enteroid-Based Models for Cryptosporidium Bhalchandra, S., et al. | November 9, 2020 Cryptosporidium is a leading cause of diarrhea and death in young children and untreated AIDS patients…eabramovichNovember 9, 2020 Read More
Publications of the Week Cell Type-Specific Lipid Storage Changes in Parkinson’s Disease Patient Brains Are Recapitulated by Experimental Glycolipid Disturbance Brekk, O.R., et al. | November 5, 2020 This study identified a unique lipid signature in human post-mortem Parkinson’s disease brain, wherein lipids…eabramovichNovember 5, 2020 Read More
Publications of the Week Modulating Androgen Receptor-Driven Transcription in Prostate Cancer with Selective CDK9 Inhibitors Richters, A., et al. | November 2, 2020 In pursuit of mechanistically novel modulators of androgen receptor, the authors have discovered a potent,…eabramovichNovember 2, 2020 Read More
Publications of the Week GATA6 Mutations in hiPSCs Inform Mechanisms for Maldevelopment of the Heart, Pancreas, and Diaphragm Sharma, A., et al. | October 29, 2020 In collaboration with the NIH’s Pediatric Cardiac Genomics Consortium, the authors sequenced thousands of children…eabramovichOctober 29, 2020 Read More
Publications of the Week Augmenting Emergency Granulopoiesis with CpG Conditioned Mesenchymal Stromal Cells in Murine Neutropenic Sepsis Ng, J., et al. | October 28, 2020 Emergency granulopoiesis, or the de novo generation of neutrophils in response to a systemic infection…eabramovichOctober 28, 2020 Read More
Publications of the Week Persistence and Decay of Human Antibody Responses to the Receptor Binding Domain of SARS-CoV-2 Spike Protein in COVID-19 Patients Iyer, A.S., et al. | October 26, 2020 The authors show that antibody responses to the receptor binding domain of the spike protein…eabramovichOctober 26, 2020 Read More