Publications of the Week Higher-Order Protein Assembly Controls Kinetochore FormationSissoko, G., et al. | January 5, 2024To faithfully segregate chromosomes during vertebrate mitosis, kinetochore–microtubule interactions must be restricted to a single…karnottJanuary 5, 2024 Read More
Publications of the Week KCTD1/KCTD15 Complexes Control Ectodermal and Neural Crest Cell Functions and Their Impairment Causes Aplasia CutisThe Journal of Clinical Investigation | January 4, 2024Aplasia cutis congenita (ACC) is a congenital epidermal defect of the midline scalp and has…karnottJanuary 4, 2024 Read More
Publications of the Week Structures, Functions, and Adaptations of the Human LINE-1 ORF2 ProteinBaldwin, E., et al. | January 3, 2024The LINE-1 (L1) retrotransposon is an ancient genetic parasite that has written around one third…karnottJanuary 3, 2024 Read More
Publications of the Week Nanoparticle-Mediated Delivery of Anti-PU.1 siRNA via Localized Intracisternal Administration Reduces NeuroinflammationRalvenius, W., et al. | December 15, 2023Neuroinflammation is a hallmark of neurodegenerative disorders including Alzheimer's disease (AD). Microglia, the brain's immune…karnottDecember 15, 2023 Read More
Publications of the Week Lymph Node Stromal Cell Responses to Perinatal T Cell Waves, a Temporal AtlasJayewickreme, T., et al. | December 14, 2023Early life poses the challenge of establishing an immune system tolerant to self while still…karnottDecember 14, 2023 Read More
Publications of the Week RvE1 Promotes Axin2+ Cell Regeneration and Reduces Bacterial InvasionWu, Y., et al. | December 11, 2023Vital pulp therapy and root canal therapy (RCT) are the dominant treatment for irreversible pulpitis.…karnottDecember 11, 2023 Read More
Publications of the Week Optimization of Base Editors for the Functional Correction of SMN2 as a Treatment for Spinal Muscular AtrophyAlves, C., et al. | December 7, 2023Spinal muscular atrophy (SMA) is caused by mutations in SMN1. SMN2 is a paralogous gene…karnottDecember 7, 2023 Read More
Publications of the Week Dictionary of Immune Responses to Cytokines at Single-Cell ResolutionCui, A., et al. | December 7, 2023Cytokines mediate cell–cell communication in the immune system and represent important therapeutic targets. A myriad…karnottDecember 7, 2023 Read More
Publications of the Week Controlling Donor and Newborn Neuron Migration and Maturation in the Eye Through Microenvironment EngineeringSoucy, J., et al. | November 28, 2023The “in silico–in vitro–in vivo” funnel holds significant potential for identifying targets to control cellular…karnottNovember 28, 2023 Read More
Publications of the Week iPSC-Derived Microglia Carrying the TREM2 R47H/+ Mutation Are Proinflammatory and Promote Synapse LossPenney, J., et al. | November 27, 2023karnottNovember 27, 2023 Read More