Publications of the Week Types and Functions of Heterogeneity in Mycobacteria Chung, E. S., et al. | April 8, 2022 The remarkable ability of Mycobacterium tuberculosis to survive attacks from the host immune response and drug treatment…pthomsonApril 8, 2022 Read More
Publications of the Week Stitchr: Stitching Coding TCR Nucleotide Sequences from V/J/CDR3 Information Heather, J. M., et al. | April 5, 2022 The study and manipulation of T cell receptors (TCRs) is central to multiple fields across…pthomsonApril 5, 2022 Read More
Publications of the Week Orthogonally Induced Differentiation of Stem Cells for the Programmatic Patterning of Vascularized Organoids and Bioprinted Tissues Sylar-Scott, M. A., et al. | April 1, 2022 The generation of organoids and tissues with programmable cellular complexity, architecture and function would benefit…pthomsonApril 1, 2022 Read More
Publications of the Week HLA Autoimmune Risk Alleles Restrict the Hypervariable Region of T Cell Receptors Ishigaki, K., et al. | March 30, 2022 Polymorphisms in the human leukocyte antigen (HLA) genes strongly influence autoimmune disease risk. HLA risk alleles may…pthomsonMarch 30, 2022 Read More
Publications of the Week Human Organs-on-Chips for Disease Modelling, Drug Development and Personalized Medicine Nature Reviews Genetics | March 25, 2022 The failure of animal models to predict therapeutic responses in humans is a major problem…pthomsonMarch 25, 2022 Read More
Publications of the Week Time-Series Transcriptomics and Proteomics Reveal Alternative Modes to Decode p53 Oscillations Jiménez, A., & Lu, D., et al. | March 24, 2022 The cell stress-responsive transcription factor p53 influences the expression of its target genes and subsequent…pthomsonMarch 24, 2022 Read More
Publications of the Week Silent Mutations Reveal Therapeutic Vulnerability in RAS Q61 Cancers Kobayashi, Y., et al. | March 18, 2022 RAS family members are the most frequently mutated oncogenes in human cancers. Although KRAS(G12C)-specific inhibitors…pthomsonMarch 18, 2022 Read More
Publications of the Week Mitochondrial Variant Enrichment from High-Throughput Single-Cell RNA Sequencing Resolves Clonal Populations Miller, T. E., et al. | March 15, 2022 The Van Galen Laboratory studies molecular mechanisms that sustain the human blood system throughout life.…pthomsonMarch 15, 2022 Read More
Publications of the Week Secondary Structural Ensembles of the SARS-CoV-2 RNA Genome in Infected Cells Lan, T. C. T., et al. | March 11, 2022 SARS-CoV-2 is a betacoronavirus with a single-stranded, positive-sense, 30-kilobase RNA genome responsible for the ongoing…pthomsonMarch 11, 2022 Read More
Publications of the Week Seipin Forms a Flexible Cage at Lipid Droplet Formation Sites Arlt, H., et al. | March 8, 2022 Lipid droplets (LDs) form in the endoplasmic reticulum by phase separation of neutral lipids. This…pthomsonMarch 8, 2022 Read More