Publications of the Week An Engineered CRISPR-Cas9 Mouse Line for Simultaneous Readout of Lineage Histories and Gene Expression Profiles in Single CellsBowling, S., et al. | May 22, 2020Tracing the lineage history of cells is key to answering diverse and fundamental questions in…eabramovichMay 22, 2020 Read More
Publications of the Week Facultative Protein Selenation Regulates Redox Sensitivity, Adipose Tissue Thermogenesis, and ObesityJedrychowski, M.P., et al. | May 18, 2020Oxidation of cysteines by reactive oxygen species (ROS) initiates thermogenesis in brown and beige adipose…eabramovichMay 18, 2020 Read More
Publications of the Week Increased Mitochondrial Calcium Levels Associated with Neuronal Death in a Mouse Model of Alzheimer’s DiseaseCalvo-Rodriguez, M., et al. | May 14, 2020This work addresses the toxic effects of the protein amyloid on the mitochondrial calcium homeostasis…eabramovichMay 14, 2020 Read More
Publications of the Week Proteomic and Biological Profiling of Extracellular Vesicles from Alzheimer’s Disease Human Brain TissuesMuraoka, S., et al. | May 12, 2020This publication is the first comprehensive quantitative proteomics study of extracellular vesicles (EV) isolated from…eabramovichMay 12, 2020 Read More
Publications of the Week Factors Promoting Nuclear Envelope Assembly Independent of the Canonical ESCRT PathwayLee, I., et al. | May 7, 2020The nuclear envelope (NE) undergoes dynamic remodeling to maintain NE integrity, a process involving the…eabramovichMay 7, 2020 Read More
Publications of the Week Disease-Associated Astrocytes in Alzheimer’s Disease and AgingHabib, N., et al. | May 5, 2020The role of non-neuronal cells in Alzheimer’s disease progression has not been fully elucidated. Using…eabramovichMay 5, 2020 Read More
Publications of the Week Mechanisms Generating Cancer Genome Complexity from a Single Cell Division ErrorUmbreit, N.T., et al. | April 30, 2020This paper addresses the mechanism for a mutational process called the chromosome breakage-fusion-bridge cycle (BFB…eabramovichApril 30, 2020 Read More
Publications of the Week A CRISPR-Based Assay for the Detection of Opportunistic Infections Post-Transplantation and for the Monitoring of Transplant RejectionKaminski, M.A., et al. | April 28, 2020In organ transplantation, infection and rejection are major causes of graft loss. They are linked…eabramovichApril 28, 2020 Read More
Publications of the Week Adhesion to Fibronectin via α5β1 Integrin Supports Expansion of Megakaryocyte Lineage in Primary MyelofibrosisMatsuura, S., et al. | April 24, 2020The authors have discovered that the megakaryocyte integrin alpha5 is significantly upregulated in primary myelofibrosis,…eabramovichApril 24, 2020 Read More
Publications of the Week Transcriptome Analysis and Functional Characterization of Cerebral Organoids in Bipolar DisorderKathuria, A., et al. | April 22, 2020Reprogramming human induced pluripotent stem cells (iPSCs) from somatic cells and generating three-dimensional brain organoids…eabramovichApril 22, 2020 Read More