Publications of the Week

Allele-specific KRAS inhibitors are an emerging class of cancer therapies. KRAS mutant (KRASMUT) non-small cell lung cancers (NSCLCs)…

Here, we study the gamete fusogen HAP2 from Cyanidioschyzon merolae (Cyani), an extremophile red algae that grows…

Receptor tyrosine kinase (RTK)–RAS signalling through the downstream mitogen-activated protein kinase (MAPK) cascade regulates cell…

Tumor microenvironment (TME) composes of multiple cell types and non-cellular components, which supports the proliferation,…

The tumor microenvironment (TME) is a unique metabolic niche that can inhibit T cell metabolism and cytotoxicity. To…

A multitude of cellular processes involve biomolecular condensates, which has led to the suggestion that…

Dr. TCW’s laboratory is aiming at human induced pluripotent stem cell therapeutics. There are two…

Deubiquitinating enzymes (DUBs), ~100 of which are found in human cells, are proteases that remove…

Actin, spectrin, and associated molecules form a membrane-associated periodic skeleton (MPS) in neurons. The molecular…

Eukaryotic cells organize their large genomes into a compacted structure called chromatin. The condensed structure…