Publications of the Week Gasdermin D Pore Structure Reveals Preferential Release of Mature Interleukin-1Xia, S., et al. | April 30, 2021As organelles of the innate immune system, inflammasomes activate caspase-1 and other inflammatory caspases that…pthomsonApril 30, 2021 Read More
Publications of the Week Single-Cell Analysis of FOXP3 Deficiencies in Humans and Mice Unmasks Intrinsic and Extrinsic CD4+ T Cell PerturbationsZemmour, D., et al. | April 26, 2021FOXP3 deficiency in mice and in patients with immune dysregulation polyendocrinopathy enteropathy X-linked (IPEX) syndrome results…pthomsonApril 26, 2021 Read More
Publications of the Week Shutoff of Host Transcription Triggers a Toxin-Antitoxin System to Cleave Phage RNA and Abort InfectionGuegler, C. K., et al. | April 23, 2021Toxin-antitoxin (TA) systems are widespread in bacteria, but their activation mechanisms and bona fide targets…pthomsonApril 23, 2021 Read More
Publications of the Week The MicroRNA miR-696 is Regulated by SNARK and Reduces Mitochondrial Activity in Mouse Skeletal Muscle Through Pgc1α InhibitionQueiroz, A.L., et al. | April 20, 2021MicroRNAs (miRNA) are known to regulate expression of genes involved in several physiological processes including…pthomsonApril 20, 2021 Read More
Publications of the Week Chemokines and the Immune Response to CancerOzga, A. J., et al. | April 16, 2021Chemokines are chemotactic cytokines that regulate the migration of immune cells. Chemokines function as cues…pthomsonApril 16, 2021 Read More
Publications of the Week A RIPK1-Regulated Inflammatory Microglial State in Amyotrophic Lateral SclerosisMifflin, L., et al. | April 14, 2021Microglial-derived inflammation has been linked to a broad range of neurodegenerative and neuropsychiatric conditions, including…pthomsonApril 14, 2021 Read More
Publications of the Week TGF‐β‐Secreting Regulatory B Cells: Unsung Players in Immune RegulationHuai, G., et al. | April 8, 2021Regulatory B cells contribute to the regulation of immune responses in cancer, autoimmune disorders, allergic…pthomsonApril 8, 2021 Read More
Publications of the Week Balancing Cohesin Eviction and Retention Prevents Aberrant Chromosomal Interactions, Polycomb-Mediated Repression, and X-InactivationKriz, A. J., et al. | April 7, 2021Depletion of architectural factors globally alters chromatin structure but only modestly affects gene expression. We revisit the…pthomsonApril 7, 2021 Read More
Publications of the Week Deep-Sea Microbes as Tools to Refine the Rules of Innate Immune Pattern RecognitionGauthier, A. E., et al. | March 31, 2021Dr. Kagan is interested in the ways that cells interact with each other and with…pthomsonMarch 31, 2021 Read More
Publications of the Week Understanding Transcription across Scales: From Base Pairs to ChromosomesVos, S. M. | March 29, 2021The influence of genome organization on transcription is central to our understanding of cell type…pthomsonMarch 29, 2021 Read More