Publications of the Week

A regular heartbeat is essential to vertebrate life. In the mature heart, this function is…

Apicomplexan parasites discharge specialized organelles called rhoptries upon host cell contact to mediate invasion. The…

Sphingolipids are required for diverse biological functions and are degraded by specific catabolic enzymes. However,…

Sporadic early-onset Alzheimer's disease (EOAD; symptomatic onset <65 years) is a rare and understudied but…

Huntington’s disease (HD) is a devastating monogenic neurodegenerative disease characterized by early, selective pathology in…

Carcinogen exposure is strongly associated with enhanced cancer immunogenicity. Increased tumor mutational burden and resulting…

Immunotherapy failures can result from the highly suppressive tumour microenvironment that characterizes aggressive forms of…

Differences in chromatin state inherited from the parental gametes influence the regulation of maternal and…

Cellular lineage histories and their molecular states encode fundamental principles of tissue development and homeostasis.…

Intrinsically disordered regions (IDRs) represent a large percentage of overall nuclear protein content. The prevailing…