Early life poses the challenge of establishing an immune system tolerant to self while still…
karnottDecember 14, 2023
Spinal muscular atrophy (SMA) is caused by mutations in SMN1. SMN2 is a paralogous gene…
karnottDecember 7, 2023
Cytokines mediate cell–cell communication in the immune system and represent important therapeutic targets. A myriad…
karnottDecember 7, 2023
The “in silico–in vitro–in vivo” funnel holds significant potential for identifying targets to control cellular…
karnottNovember 28, 2023
PIK3CA mutations occur in ~8% of cancers, including ~40% of HR-positive breast cancers, where the…
sciencecityNovember 24, 2023
DNA methyltransferases (DNMTs) are increased in neuroendocrine prostate cancer (NEPC), an aggressive cancer associated with…
sciencecityNovember 22, 2023
Mutations in SNCA, the gene encoding α-synuclein (αSyn), cause familial Parkinson’s disease (PD) and aberrant…
sciencecityNovember 20, 2023
DGKα/ζ Inhibitors Combine with PD-1 Checkpoint Therapy to Promote T Cell–Mediated Antitumor Immunity
Read the Publication This week, Science in Boston profiles Dr. Michael Wichroski (pictured). Dr. Wichroski…
sciencecityNovember 16, 2023
