Publications of the Week

Although circulating tumor DNA (ctDNA) assays are increasingly used to inform clinical decisions in cancer…

Mammalian SWI/SNF chromatin remodeling complexes move and evict nucleosomes at gene promoters and enhancers to…

The surgical resection of solid tumours can be enhanced by fluorescence-guided imaging. However, variable tumour…

A regular heartbeat is essential to vertebrate life. In the mature heart, this function is…

Apicomplexan parasites discharge specialized organelles called rhoptries upon host cell contact to mediate invasion. The…

Sphingolipids are required for diverse biological functions and are degraded by specific catabolic enzymes. However,…

Sporadic early-onset Alzheimer's disease (EOAD; symptomatic onset <65 years) is a rare and understudied but…

Huntington’s disease (HD) is a devastating monogenic neurodegenerative disease characterized by early, selective pathology in…

Carcinogen exposure is strongly associated with enhanced cancer immunogenicity. Increased tumor mutational burden and resulting…

Immunotherapy failures can result from the highly suppressive tumour microenvironment that characterizes aggressive forms of…