Publications of the Week Nuclear Release of eIF1 Restricts Start-Codon Selection During MitosisLy, J., et al. | November 4, 2024Regulated start-codon selection has the potential to reshape the proteome through the differential production of…karnottNovember 4, 2024 Read More
Publications of the Week Anti-Viral Defence by an mRNA ADP-Ribosyltransferase That Blocks TranslationVassallo, C., et al. | November 1, 2024Host-pathogen conflicts are crucibles of molecular innovation1,2. Selection for immunity to pathogens has driven the…karnottNovember 1, 2024 Read More
Publications of the Week AKT and EZH2 Inhibitors Kill TNBCs by Hijacking Mechanisms of InvolutionSchade, A., et al. | October 31, 2024Triple-negative breast cancer (TNBC) is the most aggressive breast cancer subtype and has the highest…karnottOctober 31, 2024 Read More
Publications of the Week Non-Pathogenic E. coli Displaying Decoy-Resistant IL18 Mutein Boosts Anti-Tumor and CAR NK Cell ResponsesYang, S., et al. | October 28, 2024This week, we profile a recent publication in Nature Biotechnology by Dr. Rizwan Romee from…karnottOctober 28, 2024 Read More
Publications of the Week Dopamine Dynamics Are Dispensable for Movement but Promote Reward ResponsesCai, X., et al. | October 23, 2024Dopamine signalling modes differ in kinetics and spatial patterns of receptor activation. How these modes…karnottOctober 23, 2024 Read More
Publications of the Week Transferrin Receptor Targeting Chimeras for Membrane Protein DegradationZhang, D., et al. | October 21, 2024Cancer cells require high levels of iron for rapid proliferation, leading to significant upregulation of…karnottOctober 21, 2024 Read More
Publications of the Week CDK5–Cyclin B1 Regulates Mitotic FidelityZheng, X., et al. | October 17, 2024CDK1 has been known to be the sole cyclin-dependent kinase (CDK) partner of cyclin B1…karnottOctober 17, 2024 Read More
Publications of the Week CRISPR-Based Rapid Molecular Diagnostic Tests for Fusion-Driven LeukemiasVedula, R., et al. | October 14, 2024Fusion oncogenes can be cancer-defining molecular alterations that are essential for diagnosis and therapy selection.1,2…karnottOctober 14, 2024 Read More
Publications of the Week Virally Delivered CMYA5 Enhances the Assembly of Cardiac DyadsLu, F., et al. | October 10, 2024Cardiomyocytes derived from human induced pluripotent stem cells (hiPSC-CMs) lack nanoscale structures essential for efficient…karnottOctober 10, 2024 Read More
Publications of the Week Age-Associated Contraction of Tumor-Specific T Cells Impairs Antitumor ImmunityGeorgiev, P., et al. | October 8, 2024Progressive decline of the adaptive immune system with increasing age coincides with a sharp increase…karnottOctober 8, 2024 Read More