Publications of the Week Proteogenomic Characterization of Primary Colorectal Cancer and Metastatic Progression Identifies Proteome-Based Subtypes and Signatures Tanaka, A., et al. | March 8, 2024 Metastatic progression of colorectal adenocarcinoma (CRC) remains poorly understood and poses significant challenges for treatment.…karnottMarch 8, 2024 Read More
Publications of the Week SOX17 Enables Immune Evasion of Early Colorectal Adenomas and Cancers Goto, N., et al. | March 6, 2024 A hallmark of cancer is the avoidance of immune destruction. This process has been primarily…karnottMarch 6, 2024 Read More
Publications of the Week Genetic Drivers of Heterogeneity in Type 2 Diabetes Pathophysiology Suzuki, K., et al. | March 4, 2024 Type 2 diabetes (T2D) is a heterogeneous disease that develops through diverse pathophysiological processes1,2 and…karnottMarch 4, 2024 Read More
Publications of the Week Distinct Negative Elongation Factor Conformations Regulate RNA Polymerase II Promoter-Proximal Pausing Su, B., et al. | March 1, 2024 Metazoan gene expression regulation involves pausing of RNA polymerase (Pol II) in the promoter-proximal region…karnottMarch 1, 2024 Read More
Publications of the Week Integrative Analyses of Tumor and Peripheral Biomarkers in the Treatment of Advanced Renal Cell Carcinoma Choueiri, T., et al. | February 28, 2024 The phase III JAVELIN Renal 101 trial demonstrated prolonged progression-free survival (PFS) in patients (N = 886)…karnottFebruary 28, 2024 Read More
Publications of the Week Genetic Architecture and Biology of Youth-Onset Type 2 Diabetes Kwak, S., et al. | February 26, 2024 The prevalence of youth-onset type 2 diabetes (T2D) and childhood obesity has been rising steadily1,…karnottFebruary 26, 2024 Read More
Publications of the Week Capivasertib Combines with Docetaxel to Enhance Anti-Tumour Activity Through Inhibition of AKT-Mediated Survival Mechanisms in Prostate Cancer Eberlein, C., et al. | February 23, 2024 Combining docetaxel and capivasertib had increased activity in PTEN null and WT prostate tumour models…karnottFebruary 23, 2024 Read More
Publications of the Week Genome-Wide Association Study Identifies Human Genetic Variants Associated with Fatal Outcome from Lassa Fever Kotliar, D., et al. | February 19, 2024 Infection with Lassa virus (LASV) can cause Lassa fever, a haemorrhagic illness with an estimated…karnottFebruary 19, 2024 Read More
Publications of the Week Enhancing Cancer Immunotherapy via Inhibition of Soluble Epoxide Hydrolase Kelly, A., et al. | February 13, 2024 While immunotherapy is a front-line cancer treatment, unresolved chronic inflammation and toxicities often limit its…karnottFebruary 13, 2024 Read More
Publications of the Week Direct Reprogramming of Non-limb Fibroblasts to Cells with Properties of Limb Progenitors Atsuta, Y., et al. | February 12, 2024 The early limb bud consists of mesenchymal limb progenitors derived from the lateral plate mesoderm…karnottFebruary 12, 2024 Read More