Publications of the Week Eliciting a Single Amino Acid Change by Vaccination Generates Antibody Protection Against Group 1 and Group 2 Influenza a Viruses Ray, R., et al. | May 8, 2024 Broadly neutralizing antibodies (bnAbs) targeting the hemagglutinin (HA) stem of influenza A viruses (IAVs) tend…karnottMay 8, 2024 Read More
Publications of the Week Disease Related Changes in ATAC-Seq of iPSC-Derived Motor Neuron Lines from ALS Patients and Controls Tsitkov, S., et al. | May 6, 2024 Amyotrophic Lateral Sclerosis (ALS), like many other neurodegenerative diseases, is highly heritable, but with only…karnottMay 6, 2024 Read More
Publications of the Week Epigenetic Modulation Through BET Bromodomain Inhibitors as a Novel Therapeutic Strategy for Progranulin-Deficient Frontotemporal Dementia Rosenthal, Z., et al. | May 3, 2024 Frontotemporal dementia (FTD) is a debilitating neurodegenerative disorder with currently no disease-modifying treatment options available.…karnottMay 3, 2024 Read More
Publications of the Week Placental Senescence Pathophysiology Is Shared Between Peripartum Cardiomyopathy and Preeclampsia in Mouse and Human | April 30, 2024 Peripartum cardiomyopathy is a form of heart failure linked to preeclampsia. Roh et al. found that secreted…karnottApril 30, 2024 Read More
Publications of the Week Glial Activity Load on PET Reveals Persistent “Smoldering” Inflammation in MS Despite Disease-Modifying Treatment Tarun, S., et al. | April 30, 2024 18F-PBR06-PET targeting 18-kDa translocator protein can detect abnormal microglial activation (MA) in multiple sclerosis (MS).…karnottApril 30, 2024 Read More
Publications of the Week Autonomous Circadian Rhythms in the Human Hepatocyte Regulate Hepatic Drug Metabolism and Inflammatory Responses Science Advances | April 25, 2024 Critical aspects of physiology and cell function exhibit self-sustained ~24-hour variations termed circadian rhythms. In…karnottApril 25, 2024 Read More
Publications of the Week An Esophagus Cell Atlas Reveals Dynamic Rewiring During Active Eosinophilic Esophagitis and Remission Ding, J., et al. | April 24, 2024 Coordinated cell interactions within the esophagus maintain homeostasis, and disruption can lead to eosinophilic esophagitis…karnottApril 24, 2024 Read More
Publications of the Week BCAA-Nitrogen Flux in Brown Fat Controls Metabolic Health Independent of Thermogenesis Verkerke, A., et al. | April 23, 2024 Brown adipose tissue (BAT) is best known for thermogenesis. Rodent studies demonstrated that enhanced BAT…karnottApril 23, 2024 Read More
Publications of the Week Targeted Therapies Prime Oncogene-Driven Lung Cancers for Macrophage-Mediated Destruction Vaccaro, K., et al. | April 19, 2024 Macrophage immune checkpoint inhibitors, such as anti-CD47 antibodies, show promise in clinical trials for solid…karnottApril 19, 2024 Read More
Publications of the Week Episymbiotic Saccharibacteria TM7x Modulates the Susceptibility of Its Host Bacteria to Phage Infection and Promotes Their Coexistence Zhong, Q., et al. | April 15, 2024 The factors influencing the interaction between phages and bacteria, as well as their long-term coexistence,…karnottApril 15, 2024 Read More