Publications of the Week Disruption of the IL-33-ST2-AKT Signaling Axis Impairs Neurodevelopment by Inhibiting Microglial Metabolic Adaptation and Phagocytic FunctionHe, D., et al. | January 14, 2022To accommodate the changing needs of the developing brain, microglia must undergo substantial morphological, phenotypic,…pthomsonJanuary 14, 2022 Read More
Publications of the Week Modulation of Sensory Perception by Hydrogen Peroxide Enables Caenorhabditis elegans to Find a Niche That Provides Both Food and Protection from Hydrogen PeroxideSchiffer, J. A., & Stumbur, S. V., et al. | January 7, 2022Hydrogen peroxide (H2O2) is the most common chemical threat that organisms face. Here, we show…pthomsonJanuary 7, 2022 Read More
Publications of the Week CDH1 Germline Variants Are Enriched in Patients with Colorectal Cancer, Gastric Cancer, and Breast CancerAdib, E., et al. | January 6, 2022CDH1 germline variants have been linked to heritability in diffuse gastric (DGC) and lobular breast cancer…pthomsonJanuary 6, 2022 Read More
Publications of the Week Photoacoustic Nanodroplets for Oxygen Enhanced Photodynamic Therapy of CancerXavierselvan M., et al. | December 16, 2021Photodynamic therapy (PDT) is a well-known cancer therapy that utilizes light to excite a photosensitizer and generate cytotoxic reactive…pthomsonDecember 16, 2021 Read More
Publications of the Week Wolbachia cifB Induces Cytoplasmic Incompatibility in the Malaria Mosquito VectorAdams, K. L., & Abernathy, D. et al. | December 15, 2021Wolbachia, a maternally inherited intracellular bacterial species, can manipulate host insect reproduction by cytoplasmic incompatibility…pthomsonDecember 15, 2021 Read More
Publications of the Week LSD1 Inhibition Sustains T Cell Invigoration with a Durable Response to PD-1 BlockadeLiu, Y., et al. | December 10, 2021Exhausted CD8+ T cells are key targets of immune checkpoint blockade therapy and their ineffective reinvigoration…pthomsonDecember 10, 2021 Read More
Publications of the Week Microenvironment Drives Cell State, Plasticity, and Drug Response in Pancreatic CancerRaghavan, S., et al. | December 8, 2021Prognostically relevant RNA expression states exist in pancreatic ductal adenocarcinoma (PDAC), but our understanding of…pthomsonDecember 8, 2021 Read More
Publications of the Week Glucose Metabolism and Pyruvate Carboxylase Enhance Glutathione Synthesis and Restrict Oxidative Stress in Pancreatic IsletsFu, A., et al. | December 3, 2021Glucose metabolism modulates the islet β cell responses to diabetogenic stress, including inflammation. Here, we…pthomsonDecember 3, 2021 Read More
Publications of the Week Intercellular Nanotubes Mediate Mitochondrial Trafficking between Cancer and Immune CellsSaha, T., et al. | December 2, 2021Cancer progresses by evading the immune system. Elucidating diverse immune evasion strategies is a critical…pthomsonDecember 2, 2021 Read More
Publications of the Week Reprogramming NK Cells and Macrophages via Combined Antibody and Cytokine Therapy Primes Tumors for Elimination by Checkpoint BlockadeWang, C., et al. | November 26, 2021Treatments aiming to augment immune checkpoint blockade (ICB) in cancer often focus on T cell immunity,…pthomsonNovember 26, 2021 Read More