Publications of the Week Cryptic Splicing of Stathmin-2 and UNC13A mRNAs Is a Pathological Hallmark of TDP-43-Associated Alzheimer’s Disease Almeida Quadros, A., et al. | February 9, 2024 Nuclear clearance and cytoplasmic accumulations of the RNA-binding protein TDP-43 are pathological hallmarks in almost…karnottFebruary 9, 2024 Read More
Publications of the Week Improved Immunostaining of Nanostructures and Cells in Human Brain Specimens Through Expansion-Mediated Protein Decrowding Valdes, P., et al. | February 7, 2024 Proteins are densely packed in cells and tissues, where they form complex nanostructures. Expansion microscopy…karnottFebruary 7, 2024 Read More
Publications of the Week CAG Repeat Expansions Create Splicing Acceptor Sites and Produce Aberrant Repeat-Containing RNAs Anderson, R., et al. | February 5, 2024 Expansions of CAG trinucleotide repeats cause several rare neurodegenerative diseases. The disease-causing repeats are translated…karnottFebruary 5, 2024 Read More
Publications of the Week HIV-1 Capsids Enter the Fg Phase of Nuclear Pores like a Transport Receptor Fu, L., et al. | February 2, 2024 HIV-1 infection requires nuclear entry of the viral genome. Previous evidence suggests that this entry…karnottFebruary 2, 2024 Read More
Publications of the Week AAV1-hOTOF Gene Therapy for Autosomal Recessive Deafness 9: A Single-Arm Trial Lv, J., et al. | February 1, 2024 Autosomal recessive deafness 9, caused by mutations of the OTOF gene, is characterised by congenital or prelingual,…karnottFebruary 1, 2024 Read More
Publications of the Week Enhancing Antibody Responses by Multivalent Antigen Display on Thymus-Independent DNA Origami Scaffolds Wamhoff, E., et al. | January 30, 2024 Protein-based virus-like particles (P-VLPs) are commonly used to spatially organize antigens and enhance humoral immunity…karnottJanuary 30, 2024 Read More
Publications of the Week Priming Agents Transiently Reduce the Clearance of Cell-Free DNA to Improve Liquid Biopsies Martin-Alonso, C., et al. | January 26, 2024 Liquid biopsy for tumor analysis offers the potential for noninvasive access using a blood draw…karnottJanuary 26, 2024 Read More
Publications of the Week Inherited Blood Cancer Predisposition Through Altered Transcription Elongation Zhao, J., et al. | January 23, 2024 Despite advances in defining diverse somatic mutations that cause myeloid malignancies, a significant heritable component…karnottJanuary 23, 2024 Read More
Publications of the Week Noninvasive Detection of Neuroendocrine Prostate Cancer Through Targeted Cell-Free DNA Methylation Franceschini, G., et al. | January 18, 2024 Castration-resistant prostate cancer (CRPC) is a heterogeneous disease associated with phenotypic subtypes that drive therapy…karnottJanuary 18, 2024 Read More
Publications of the Week Long-Term Labeling and Imaging of Synaptically Connected Neuronal Networks In Vivo Using Double-Deletion-Mutant Rabies Viruses Jin, L., et al. | January 16, 2024 Rabies-virus-based monosynaptic tracing is a widely used technique for mapping neural circuitry, but its cytotoxicity…karnottJanuary 16, 2024 Read More