Publications of the Week Stitchr: Stitching Coding TCR Nucleotide Sequences from V/J/CDR3 InformationHeather, J. M., et al. | April 5, 2022The study and manipulation of T cell receptors (TCRs) is central to multiple fields across…pthomsonApril 5, 2022 Read More
Publications of the Week Orthogonally Induced Differentiation of Stem Cells for the Programmatic Patterning of Vascularized Organoids and Bioprinted TissuesSylar-Scott, M. A., et al. | April 1, 2022The generation of organoids and tissues with programmable cellular complexity, architecture and function would benefit…pthomsonApril 1, 2022 Read More
Publications of the Week HLA Autoimmune Risk Alleles Restrict the Hypervariable Region of T Cell ReceptorsIshigaki, K., et al. | March 30, 2022Polymorphisms in the human leukocyte antigen (HLA) genes strongly influence autoimmune disease risk. HLA risk alleles may…pthomsonMarch 30, 2022 Read More
Publications of the Week Human Organs-on-Chips for Disease Modelling, Drug Development and Personalized MedicineNature Reviews Genetics | March 25, 2022The failure of animal models to predict therapeutic responses in humans is a major problem…pthomsonMarch 25, 2022 Read More
Publications of the Week Time-Series Transcriptomics and Proteomics Reveal Alternative Modes to Decode p53 OscillationsJiménez, A., & Lu, D., et al. | March 24, 2022The cell stress-responsive transcription factor p53 influences the expression of its target genes and subsequent…pthomsonMarch 24, 2022 Read More
Publications of the Week Silent Mutations Reveal Therapeutic Vulnerability in RAS Q61 CancersKobayashi, Y., et al. | March 18, 2022RAS family members are the most frequently mutated oncogenes in human cancers. Although KRAS(G12C)-specific inhibitors…pthomsonMarch 18, 2022 Read More
Publications of the Week Mitochondrial Variant Enrichment from High-Throughput Single-Cell RNA Sequencing Resolves Clonal PopulationsMiller, T. E., et al. | March 15, 2022The Van Galen Laboratory studies molecular mechanisms that sustain the human blood system throughout life.…pthomsonMarch 15, 2022 Read More
Publications of the Week Secondary Structural Ensembles of the SARS-CoV-2 RNA Genome in Infected CellsLan, T. C. T., et al. | March 11, 2022SARS-CoV-2 is a betacoronavirus with a single-stranded, positive-sense, 30-kilobase RNA genome responsible for the ongoing…pthomsonMarch 11, 2022 Read More
Publications of the Week Seipin Forms a Flexible Cage at Lipid Droplet Formation SitesArlt, H., et al. | March 8, 2022Lipid droplets (LDs) form in the endoplasmic reticulum by phase separation of neutral lipids. This…pthomsonMarch 8, 2022 Read More
Publications of the Week Molecular Catastrophe, the Peritoneal Cavity, and Ovarian Cancer PreventionYoon, J. Y., et al. | March 4, 2022The current theory of carcinogenesis for the deadliest of "ovarian" cancers - high-grade serous carcinoma…pthomsonMarch 4, 2022 Read More