Publications of the Week Widespread Neuroanatomical Integration and Distinct Electrophysiological Properties of Glioma-Innervating Neurons Hsieh, A., et al. | December 16, 2024 We developed a system utilizing rabies virus–based monosynaptic tracing to visualize neurons that synapse onto…karnottDecember 16, 2024 Read More
Publications of the Week A Tetramer of BCL11A Is Required for Stable Protein Production and Fetal Hemoglobin Silencing Zheng, G., et al. | December 12, 2024 BCL11A is a transcription factor involved in the development of the brain and hematopoietic (blood)…karnottDecember 12, 2024 Read More
Publications of the Week Genomic Heterogeneity and Ploidy Identify Patients with Intrinsic Resistance to PD-1 Blockade in Metastatic Melanoma Tarantino, G., et al. | December 9, 2024 The introduction of immune checkpoint blockade (ICB) has markedly improved outcomes for advanced melanoma. However,…karnottDecember 9, 2024 Read More
Publications of the Week Proteolethargy Is a Pathogenic Mechanism in Chronic Disease Dall’Agnese, A., et al. | December 4, 2024 The pathogenic mechanisms of many diseases are well understood at the molecular level, but there…karnottDecember 4, 2024 Read More
Publications of the Week Jellyfish for the Study of Nervous System Evolution and Function Cunningham, K., et al. | December 2, 2024 Jellyfish comprise a diverse clade of free-swimming predators that arose prior to the Cambrian explosion.…karnottDecember 2, 2024 Read More
Publications of the Week Evolving Cell States and Oncogenic Drivers During the Progression of IDH-Mutant Gliomas Wu, J., et al. | November 29, 2024 Isocitrate dehydrogenase (IDH) mutants define a class of gliomas that are initially slow-growing but inevitably…karnottNovember 29, 2024 Read More
Publications of the Week Tumor Integrin-Targeted Glucose Oxidase Enzyme Promotes ROS-Mediated Cell Death That Combines with Interferon Alpha Therapy for Tumor Control Stinson, J., et al. | November 27, 2024 Although heightened intratumoral levels of reactive oxygen species (ROS) are typically associated with a suppressive…karnottNovember 27, 2024 Read More
Publications of the Week Cephalopod-Inspired Jetting Devices for Gastrointestinal Drug Delivery Arrick, G., et al. | November 25, 2024 Needle-based injections currently enable the administration of a wide range of biomacromolecule therapies across the…karnottNovember 25, 2024 Read More
Publications of the Week Regulated GATA1 Expression as a Universal Gene Therapy for Diamond-Blackfan Anemia Voit, R., et al. | November 20, 2024 This week, we profile a recent publication in Cell Stem Cell by Dr. Vijay Sankaran…karnottNovember 20, 2024 Read More
Publications of the Week Somatic Mosaicism in Schizophrenia Brains Reveals Prenatal Mutational Processes Maury, E., et al. | November 18, 2024 Somatic mutations during brain development have been associated with several neurological disorders. Maury et al. performed…karnottNovember 18, 2024 Read More