Publications of the Week The Meninges Host a Distinct Compartment of Regulatory T Cells That Preserves Brain Homeostasis Marin-Rodero, M., et al. | February 3, 2025 Our understanding of the meningeal immune system has recently burgeoned, particularly regarding how innate and…karnottFebruary 3, 2025 Read More
Publications of the Week Variants and Vaccines Impact Nasal Immunity Over Three Waves of SARS-CoV-2 Walsh, J., et al. | January 31, 2025 Viral variant and host vaccination status impact infection with severe acute respiratory syndrome coronavirus 2…karnottJanuary 31, 2025 Read More
Publications of the Week Rickettsia parkeri Forms Extensive, Stable Contacts with the Rough Endoplasmic Reticulum Acevedo-Sánchez, Y., et al. | January 29, 2025 Upon invasion into the host cell, a subset of bacterial pathogens resides exclusively in the…karnottJanuary 29, 2025 Read More
Publications of the Week Long Somatic DNA-Repeat Expansion Drives Neurodegeneration in Huntington’s Disease Handsaker, R., et al. | January 27, 2025 In Huntington’s disease (HD), striatal projection neurons (SPNs) degenerate during midlife; the core biological question…karnottJanuary 27, 2025 Read More
Publications of the Week Structural and Functional Analysis of the Nipah Virus Polymerase Complex | January 22, 2025 Nipah virus (NiV) is a bat-borne, zoonotic RNA virus that is highly pathogenic in humans.…karnottJanuary 22, 2025 Read More
Publications of the Week Exocyst Stimulates Multiple Steps of Exocytic SNARE Complex Assembly and Vesicle Fusion Lee, C., et al. | January 20, 2025 Exocyst is a large multisubunit tethering complex essential for targeting and fusion of secretory vesicles…karnottJanuary 20, 2025 Read More
Publications of the Week In Vivo Base Editing Extends Lifespan of a Humanized Mouse Model of Prion Disease An, M., et al. | January 16, 2025 Prion disease is a fatal neurodegenerative disease caused by the misfolding of prion protein (PrP)…karnottJanuary 16, 2025 Read More
Publications of the Week Rational Engineering of Minimally Immunogenic Nucleases for Gene Therapy Raghavan, R., et al. | January 13, 2025 Genome editing using CRISPR-Cas systems is a promising avenue for the treatment of genetic diseases.…karnottJanuary 13, 2025 Read More
Publications of the Week Development of an FKBP12-Recruiting Chemical-Induced Proximity DNA-Encoded Library and Its Application to Discover an Autophagy Potentiator Tan, Z., et al. | January 9, 2025 An expanded repertoire of therapeutic tools is needed to explore and alter the function of…karnottJanuary 9, 2025 Read More
Publications of the Week The Dynamics of Hematopoiesis over the Human Lifespan | January 7, 2025 Over a lifetime, hematopoietic stem cells (HSCs) adjust their lineage output to support age-aligned physiology.…karnottJanuary 7, 2025 Read More