Publications of the Week CDK5-Cyclin B1 Regulates Mitotic Fidelity Zheng, X., et al. | September 12, 2024 CDK1 has been known to be the sole cyclin-dependent kinase (CDK) partner of cyclin B1…karnottSeptember 12, 2024 Read More
Publications of the Week Tumor Editing Suppresses Innate and Adaptive Antitumor Immunity and Is Reversed by Inhibiting DNA Methylation Zhang, Y., et al. | September 11, 2024 Cancer cells edit gene expression to evade immunosurveillance. However, genome-wide studies of gene editing during…karnottSeptember 11, 2024 Read More
Publications of the Week RAD21 Promotes Oncogenesis and Lethal Progression of Prostate Cancer Su, X., et al. | September 4, 2024 Chromosome arm 8q is the most frequently gained chromosome arm in aneuploid prostate cancer and…karnottSeptember 4, 2024 Read More
Publications of the Week Viral DNA Polymerase Structures Reveal Mechanisms of Antiviral Drug Resistance Shankar, S., et al. | September 2, 2024 DNA polymerases are important drug targets, and many structural studies have captured them in distinct…karnottSeptember 2, 2024 Read More
Publications of the Week Donepezil Nanoemulsion Induces a Torpor-like State with Reduced Toxicity in Nonhibernating Xenopus laevis Tadpoles Oliver, M., et al. | August 29, 2024 Achieving a reversible decrease of metabolism and other physiological processes in the whole organism, as…karnottAugust 29, 2024 Read More
Publications of the Week Cell-Selective Proteomics Reveal Novel Effectors Secreted by an Obligate Intracellular Bacterial Pathogen Sanderlin, A., et al. | August 26, 2024 Pathogenic bacteria secrete protein effectors to hijack host machinery and remodel their infectious niche. Rickettsia…karnottAugust 26, 2024 Read More
Publications of the Week Parsing Digital or Analog TCR Performance Through Piconewton Forces Akitsu, A., et al. | August 23, 2024 αβ T cell receptors (TCRs) principally recognize aberrant peptides bound to major histocompatibility complex molecules…karnottAugust 23, 2024 Read More
Publications of the Week The Choroid Plexus Synergizes with Immune Cells During Neuroinflammation Xu, H., et al. | August 21, 2024 The choroid plexus (ChP) is a vital brain barrier and source of cerebrospinal fluid (CSF).…karnottAugust 21, 2024 Read More
Publications of the Week Enhancing siRNA Efficacy In Vivo with Extended Nucleic Acid Backbones Yamada, K., et al. | August 16, 2024 Therapeutic small interfering RNA (siRNA) requires sugar and backbone modifications to inhibit nuclease degradation. However,…karnottAugust 16, 2024 Read More
Publications of the Week Loss of Kmt2c or Kmt2d Drives Brain Metastasis via KDM6A-Dependent Upregulation of MMP3 Seehawer, M., et al. | August 12, 2024 KMT2C and KMT2D, encoding histone H3 lysine 4 methyltransferases, are among the most commonly mutated…karnottAugust 12, 2024 Read More