Publications of the Week PI3K Drives the De Novo Synthesis of Coenzyme A from Vitamin B5Dibble, C. C, et al. | August 16, 2022This study was a collaboration between the laboratories of Dr. Christian C. Dibble and Dr.…pthomsonAugust 16, 2022 Read More
Publications of the Week Network Tau Spreading Is Vulnerable to the Expression Gradients of APOE and Glutamatergic-Related GenesMontal, V., et al. | August 12, 2022Intracellular Tau protein accumulation and spreading in the brain contribute to neurodegeneration and cognitive impairments…pthomsonAugust 12, 2022 Read More
Publications of the Week Polysaccharide and Conjugate Vaccines to Streptococcus pneumoniae Generate Distinct Humoral ResponsesDavies, L. R. L., et al. | August 11, 2022Streptococcus pneumoniae is a major cause of disease in older adults, for which two vaccines, a…pthomsonAugust 11, 2022 Read More
Publications of the Week Whole Genome Sequencing Reveals the Independent Clonal Origin of Multifocal Ileal Neuroendocrine TumorsMäkinen, N., et al. | August 5, 2022Small intestinal neuroendocrine tumors (SI-NETs) are the most common neoplasms of the small bowel. The…pthomsonAugust 5, 2022 Read More
Publications of the Week Increasing the Throughput of Sensitive Proteomics by plexDIADerks, J., et al. | August 1, 2022The Slavov lab aim to understand the rules governing emergent systems-level behavior and to use…pthomsonAugust 1, 2022 Read More
Publications of the Week Declines in Prevalence Alter the Optimal Level of Sexual Investment for the Malaria Parasite Plasmodium falciparumEarly, A. M., et al. | July 29, 2022Like most human pathogens, the malaria parasite Plasmodium falciparum experiences strong selection pressure from public health interventions…pthomsonJuly 29, 2022 Read More
Publications of the Week Dissecting the Clinicopathologic, Genomic, and Immunophenotypic Correlates of KRASG12D Mutated Non-Small Cell Lung CancerRicciuti, B., et al. | July 29, 2022Allele-specific KRAS inhibitors are an emerging class of cancer therapies. KRAS mutant (KRASMUT) non-small cell lung cancers (NSCLCs)…pthomsonJuly 29, 2022 Read More
Publications of the Week Monomeric Prefusion Structure of an Extremophile Gamete Fusogen and Stepwise Formation of the Postfusion Trimeric StateFeng, J., et al. | July 20, 2022Here, we study the gamete fusogen HAP2 from Cyanidioschyzon merolae (Cyani), an extremophile red algae that grows…pthomsonJuly 20, 2022 Read More
Publications of the Week Structure–Function Analysis of the SHOC2–MRAS–PP1C Holophosphatase ComplexKwon, J. J., et al. | July 19, 2022Receptor tyrosine kinase (RTK)–RAS signalling through the downstream mitogen-activated protein kinase (MAPK) cascade regulates cell…pthomsonJuly 19, 2022 Read More
Publications of the Week Targeting Micro-Environmental Pathways by PROTACs as a Therapeutic StrategyLiu, J., et al. | July 14, 2022Tumor microenvironment (TME) composes of multiple cell types and non-cellular components, which supports the proliferation,…pthomsonJuly 14, 2022 Read More