Publications of the Week Structural and Functional Analysis of the Nipah Virus Polymerase Complex | January 22, 2025 Nipah virus (NiV) is a bat-borne, zoonotic RNA virus that is highly pathogenic in humans.…karnottJanuary 22, 2025 Read More
Publications of the Week Exocyst Stimulates Multiple Steps of Exocytic SNARE Complex Assembly and Vesicle Fusion Lee, C., et al. | January 20, 2025 Exocyst is a large multisubunit tethering complex essential for targeting and fusion of secretory vesicles…karnottJanuary 20, 2025 Read More
Publications of the Week In Vivo Base Editing Extends Lifespan of a Humanized Mouse Model of Prion Disease An, M., et al. | January 16, 2025 Prion disease is a fatal neurodegenerative disease caused by the misfolding of prion protein (PrP)…karnottJanuary 16, 2025 Read More
Publications of the Week Rational Engineering of Minimally Immunogenic Nucleases for Gene Therapy Raghavan, R., et al. | January 13, 2025 Genome editing using CRISPR-Cas systems is a promising avenue for the treatment of genetic diseases.…karnottJanuary 13, 2025 Read More
Publications of the Week Development of an FKBP12-Recruiting Chemical-Induced Proximity DNA-Encoded Library and Its Application to Discover an Autophagy Potentiator Tan, Z., et al. | January 9, 2025 An expanded repertoire of therapeutic tools is needed to explore and alter the function of…karnottJanuary 9, 2025 Read More
Publications of the Week The Dynamics of Hematopoiesis over the Human Lifespan | January 7, 2025 Over a lifetime, hematopoietic stem cells (HSCs) adjust their lineage output to support age-aligned physiology.…karnottJanuary 7, 2025 Read More
Publications of the Week The Dlk1-Dio3 Noncoding RNA Cluster Coordinately Regulates Mitochondrial Respiration and Chromatin Structure to Establish Proper Cell State for Muscle Differentiation Icon for the Forest of Biologists Pinheiro, A., et al. | December 20, 2024 The coordinate regulation of metabolism and epigenetics to establish cell state-specific gene expression patterns during…karnottDecember 20, 2024 Read More
Publications of the Week Widespread Neuroanatomical Integration and Distinct Electrophysiological Properties of Glioma-Innervating Neurons Hsieh, A., et al. | December 16, 2024 We developed a system utilizing rabies virus–based monosynaptic tracing to visualize neurons that synapse onto…karnottDecember 16, 2024 Read More
Publications of the Week A Tetramer of BCL11A Is Required for Stable Protein Production and Fetal Hemoglobin Silencing Zheng, G., et al. | December 12, 2024 BCL11A is a transcription factor involved in the development of the brain and hematopoietic (blood)…karnottDecember 12, 2024 Read More
Publications of the Week Genomic Heterogeneity and Ploidy Identify Patients with Intrinsic Resistance to PD-1 Blockade in Metastatic Melanoma Tarantino, G., et al. | December 9, 2024 The introduction of immune checkpoint blockade (ICB) has markedly improved outcomes for advanced melanoma. However,…karnottDecember 9, 2024 Read More