Publications of the Week A Window-of-Opportunity Trial Reveals Mechanisms of Response and Resistance to Navtemadlin in Patients With Recurrent Glioblastoma Rendo, V., et al. | February 27, 2025 Many glioblastomas express wild-type TP53, which may make them susceptible to pharmacological inhibition of MDM2…karnottFebruary 27, 2025 Read More
Publications of the Week Macrophages Protect Against Sensory Axon Loss in Peripheral Neuropathy Hakim, S., et al. | February 24, 2025 Peripheral neuropathy is a common complication of type 2 diabetes, which is strongly associated with…karnottFebruary 24, 2025 Read More
Publications of the Week Mussel-Inspired Cross-Linking Mechanisms Enhance Gelation and Adhesion of Multifunctional Mucin-Derived Hydrogels Degen, G., et al. | February 20, 2025 The layers of mucus coating vulnerable surfaces in the body are composed of lubricious, bioactive…karnottFebruary 20, 2025 Read More
Publications of the Week GUK1 Activation Is a Metabolic Liability in Lung Cancer Schneider, J., et al. | February 17, 2025 Little is known about metabolic vulnerabilities in oncogene-driven lung cancer. Here, we perform a phosphoproteomic…karnottFebruary 17, 2025 Read More
Publications of the Week SKI Complex Loss Renders 9p21.3-Deleted or MSI-H Cancers Dependent on PELO Borck, J., et al. | February 14, 2025 Cancer genome alterations often lead to vulnerabilities that can be used to selectively target cancer…karnottFebruary 14, 2025 Read More
Publications of the Week Highly Multiplexed Spatial Transcriptomics in Bacteria Sarfatis, A., et al. | February 13, 2025 Many bacteria inhabit complex, spatially structured environments and exhibit behaviors not well captured by population…karnottFebruary 13, 2025 Read More
Publications of the Week First-in-Human Phase 1/2 Study (MYCHELANGELO I) of First-in-Class Epigenomic Controller OTX-2002 Targeting MYC Oncogene in Patients With Hepatocellular Carcinoma (HCC) and Other Solid Tumors. Mizrahi, J., et al. | February 11, 2025 Background: The c-MYC (MYC) oncogene is a master transcription factor of tumor cell and microenvironment…karnottFebruary 11, 2025 Read More
Publications of the Week ChromoGen: Diffusion Model Predicts Single-Cell Chromatin Conformations Schuette, G., et al. | February 7, 2025 Breakthroughs in high-throughput sequencing and microscopic imaging technologies have revealed that chromatin structures vary considerably…karnottFebruary 7, 2025 Read More
Publications of the Week AI Model Learns Generalized “Language” of Regulatory Genomics, Predicts Cellular Stories Javed, N., et al. | February 5, 2025 A team of investigators from Dana-Farber Cancer Institute, The Broad Institute of MIT and Harvard,…karnottFebruary 5, 2025 Read More
Publications of the Week The Meninges Host a Distinct Compartment of Regulatory T Cells That Preserves Brain Homeostasis Marin-Rodero, M., et al. | February 3, 2025 Our understanding of the meningeal immune system has recently burgeoned, particularly regarding how innate and…karnottFebruary 3, 2025 Read More