Publications of the Week Gut-Licensed IFNγ+ NK Cells Drive LAMP1+TRAIL+ Anti-Inflammatory AstrocytesSanmarco, L.M., et al. | January 15, 2021Astrocytes are glial cells that are abundant in the central nervous system (CNS) and that…eabramovichJanuary 15, 2021 Read More
Publications of the Week Mechanism of Filament Formation in UPA-Promoted CARD8 and NLRP1 InflammasomesHollingsworth, L.R., et al. | January 13, 2021NLRP1 and CARD8 are related cytosolic sensors that upon activation form supramolecular signalling complexes known…eabramovichJanuary 13, 2021 Read More
Publications of the Week In Vivo Base Editing Rescues Hutchinson–Gilford Progeria Syndrome in MiceKoblan, L.W., et al. | January 7, 2021Hutchinson–Gilford progeria syndrome (HGPS or progeria) is typically caused by a dominant-negative C•G-to-T•A mutation (c.1824…eabramovichJanuary 7, 2021 Read More
Publications of the Week Motif-Driven Interactions between RNA and PRC2 Are Rheostats that Regulate Transcription ElongationRosenberg, M., et al. | January 5, 2021Although polycomb repressive complex 2 (PRC2) is now recognized as an RNA-binding complex, the full…eabramovichJanuary 5, 2021 Read More
Publications of the Week SPRED1 Deletion Confers Resistance to MAPK Inhibition in MelanomaAblain, J., et al. | December 18, 2020Functional evaluation of genetic lesions can discover a role in cancer initiation and progression and…eabramovichDecember 18, 2020 Read More
Publications of the Week Dynamics of RNA Polymerase II and Elongation Factor Spt4/5 Recruitment during Activator-Dependent TranscriptionRosen, G.A., et al. | December 16, 2020The synthesis of a eukaryotic messenger RNA molecule involves the association of RNA polymerase and…eabramovichDecember 16, 2020 Read More
Publications of the Week A Macrophage-Specific lncRNA Regulates Apoptosis and Atherosclerosis by Tethering HuR in the NucleusSimion, V., et al. | December 11, 2020The authors identified a lncRNA termed MAARS that is expressed specifically in macrophages in atherosclerotic…eabramovichDecember 11, 2020 Read More
Publications of the Week Direct Tumor Killing and Immunotherapy through Anti-SerpinB9 TherapyJiang, L., et al. | December 7, 2020The authors found that serpin B9 (Sb9) prevents cancer cells from killing themselves due to…eabramovichDecember 7, 2020 Read More
Publications of the Week Tolerogenic Nanoparticles Suppress Central Nervous System InflammationKenison, J.E., et al. | December 4, 2020The authors developed a novel nanomaterial-based approach for antigen-specific immune modulation. This novel approach allows…eabramovichDecember 4, 2020 Read More
Publications of the Week Shigella flexneri Disruption of Cellular Tension Promotes Intercellular SpreadDuncan-Lowey, J.K., et al. | December 2, 2020The findings in this publication demonstrate that the gram-negative intracellular bacterial pathogen Shigella flexneri, which…eabramovichDecember 2, 2020 Read More