Publications of the Week Single-Cell Lineage Tracing Unveils a Role for TCF15 in HaematopoiesisRodriguez-Fraticelli, A.E., et al. | July 21, 2020Bone marrow transplantation therapy relies on the life-long regenerative capacity of haematopoietic stem cells (HSCs)1,2.…eabramovichJuly 21, 2020 Read More
Publications of the Week Systematic Quantitative Analysis of Ribosome Inventory During Nutrient StressAn, H., et al. | July 17, 2020Mammalian cells reorganize their proteomes in response to nutrient stress through translational suppression and degradative…eabramovichJuly 17, 2020 Read More
Publications of the Week The Evolutionarily Conserved piRNA-Producing Locus pi6 Is Required for Male Mouse FertilityWu, PH., et al. | July 14, 2020The results suggest that in mammals — including human beings — a convoluted network of…eabramovichJuly 14, 2020 Read More
Publications of the Week An Ecological Framework to Understand the Efficacy of Fecal Microbiota TransplantationXiao, Y., et al. | July 10, 2020The authors present an ecological framework to understand the efficacy of fecal microbiota transplantation (FMT)…eabramovichJuly 10, 2020 Read More
Publications of the Week Sex Differences in Gene Expression and Regulatory Networks across 29 Human TissuesLopes-Ramos, C.M., et al. | July 7, 2020The authors modeled the network of factors that control gene expression and observed that these…eabramovichJuly 7, 2020 Read More
Publications of the Week Tau Molecular Diversity Contributes to Clinical Heterogeneity in Alzheimer’s DiseaseDujardin, S., et al. | July 3, 2020Alzheimer’s disease (AD) causes unrelenting, progressive cognitive impairments, but its course is heterogeneous, with a…eabramovichJuly 3, 2020 Read More
Publications of the Week The Role of Bone Morphogenetic Protein Signaling in Non-Alcoholic Fatty Liver DiseaseThayer, T.E., et al. | July 2, 2020Despite the growing burden and high morbidity and mortality associated with non-alcoholic fatty liver disease…eabramovichJuly 2, 2020 Read More
Publications of the Week Drug GRADE: An Integrated Analysis of Population Growth and Cell Death Reveals Drug-Specific and Cancer Subtype-Specific Response ProfilesSchwartz, H.R., et al. | June 29, 2020The typical measurement for evaluating drugs doesn’t distinguish between responses that are due to inhibition…eabramovichJune 29, 2020 Read More
Publications of the Week cGMP via PKG Activates 26S Proteasomes and Enhances Degradation of Proteins, Including Ones that Cause Neurodegenerative DiseasesVerPlank, J.J.S., et al. | June 26, 2020The authors demonstrate that agents that raise cGMP and activate the cGMP-dependent protein kinase (PKG),…eabramovichJune 26, 2020 Read More
Publications of the Week Inhibition of the Translesion Synthesis Polymerase REV1 Exploits Replication Gaps as a Cancer VulnerabilityNayak, S., et al. | June 22, 2020The authors reveal how a well described anti-cancer barrier, “the replication stress response,” is overcome…eabramovichJune 22, 2020 Read More