Publications of the Week Maternal H3K27me3-Dependent Autosomal and X Chromosome ImprintingChen, Z., & Zhang, Y. | June 12, 2020Genomic imprinting and X-chromosome inactivation (XCI) are classic epigenetic phenomena that involve transcriptional silencing of…eabramovichJune 12, 2020 Read More
Publications of the Week The Perlman Syndrome DIS3L2 Exoribonuclease Safeguards Endoplasmic Reticulum-Targeted mRNA Translation and Calcium Ion HomeostasisPirouz, M., et al. | June 9, 2020DIS3L2-mediated decay (DMD) is a surveillance pathway for certain non-coding RNAs (ncRNAs) including ribosomal RNAs…eabramovichJune 9, 2020 Read More
Publications of the Week Hair-Bearing Human Skin Generated Entirely from Pluripotent Stem CellsLee, J., et al. | June 5, 2020The skin is a multilayered organ, equipped with appendages (that is, follicles and glands), that…eabramovichJune 5, 2020 Read More
Publications of the Week Loss of Heterozygosity of Essential Genes Represents a Widespread Class of Potential Cancer VulnerabilitiesNichols, C.A., et al. | June 1, 2020About one out of every six genes loses one of its two alleles in the…eabramovichJune 1, 2020 Read More
Publications of the Week Transcriptional and Cellular Diversity of the Human HeartTucker, N.R., et al. | May 28, 2020The human heart requires a complex ensemble of specialized cell types to perform its essential…eabramovichMay 28, 2020 Read More
Publications of the Week Patient hiPSCs Identify Vascular Smooth Muscle Arylacetamide Deacetylase as Protective against AtherosclerosisToyohara, T., et al. | May 25, 2020Although susceptibility to cardiovascular disease (CVD) is different for every patient, why some patients with…eabramovichMay 25, 2020 Read More
Publications of the Week An Engineered CRISPR-Cas9 Mouse Line for Simultaneous Readout of Lineage Histories and Gene Expression Profiles in Single CellsBowling, S., et al. | May 22, 2020Tracing the lineage history of cells is key to answering diverse and fundamental questions in…eabramovichMay 22, 2020 Read More
Publications of the Week Facultative Protein Selenation Regulates Redox Sensitivity, Adipose Tissue Thermogenesis, and ObesityJedrychowski, M.P., et al. | May 18, 2020Oxidation of cysteines by reactive oxygen species (ROS) initiates thermogenesis in brown and beige adipose…eabramovichMay 18, 2020 Read More
Publications of the Week Increased Mitochondrial Calcium Levels Associated with Neuronal Death in a Mouse Model of Alzheimer’s DiseaseCalvo-Rodriguez, M., et al. | May 14, 2020This work addresses the toxic effects of the protein amyloid on the mitochondrial calcium homeostasis…eabramovichMay 14, 2020 Read More
Publications of the Week Proteomic and Biological Profiling of Extracellular Vesicles from Alzheimer’s Disease Human Brain TissuesMuraoka, S., et al. | May 12, 2020This publication is the first comprehensive quantitative proteomics study of extracellular vesicles (EV) isolated from…eabramovichMay 12, 2020 Read More