Publications of the Week Cholesterol and Matrisome Pathways Dysregulated in Astrocytes and MicrogliaTCW, J., et al. | July 5, 2022Dr. TCW’s laboratory is aiming at human induced pluripotent stem cell therapeutics. There are two…pthomsonJuly 5, 2022 Read More
Publications of the Week Integrating Multi-Omics Data Reveals Function and Therapeutic Potential of Deubiquitinating EnzymesDoherty, L. M., et al. | June 29, 2022Deubiquitinating enzymes (DUBs), ~100 of which are found in human cells, are proteases that remove…pthomsonJune 29, 2022 Read More
Publications of the Week Proteomic and Functional Analyses of the Periodic Membrane Skeleton in NeuronsZhou, R., et al. | June 29, 2022Actin, spectrin, and associated molecules form a membrane-associated periodic skeleton (MPS) in neurons. The molecular…pthomsonJune 29, 2022 Read More
Publications of the Week Structural Basis of Nucleosome Retention During Transcription ElongationFilipovski, M., et al. | June 22, 2022Eukaryotic cells organize their large genomes into a compacted structure called chromatin. The condensed structure…pthomsonJune 22, 2022 Read More
Publications of the Week TET2-Mutant Clonal Hematopoiesis and Risk of GoutAgrawal, M., et al. | June 22, 2022Gout is a common inflammatory arthritis caused by precipitation of monosodium urate (MSU) crystals in…pthomsonJune 22, 2022 Read More
Publications of the Week A Brainstem Circuit for Nausea SuppressionZhang, C., et al. | June 15, 2022Nausea is a discomforting sensation of gut malaise that remains a major clinical challenge. Several…pthomsonJune 15, 2022 Read More
Publications of the Week Context-Specific Polycomb Mechanisms in DevelopmentKim, J. J., et al. | June 15, 2022Polycomb group (PcG) proteins are crucial chromatin regulators that maintain repression of lineage-inappropriate genes and…pthomsonJune 15, 2022 Read More
Publications of the Week Immunosuppression Broadens Evolutionary Pathways to Drug Resistance and Treatment Failure During Acinetobacter baumannii Pneumonia in MiceHuo, W., et al. | June 9, 2022Acinetobacter baumannii is increasingly refractory to antibiotic treatment in healthcare settings. As is true of most…pthomsonJune 9, 2022 Read More
Publications of the Week Single-Cell RNA Sequencing Reveals Evolution of Immune Landscape During Glioblastoma ProgressionYeo, A. T., et al. | June 8, 2022Glioblastoma (GBM) is an incurable primary malignant brain cancer hallmarked with a substantial protumorigenic immune…pthomsonJune 8, 2022 Read More
Publications of the Week Intracellular Sensing of DNA in Autoinflammation and AutoimmunityMacLauchlan, S., et al. | June 3, 2022DNA has emerged as a Pathogen Associated Molecular Pattern (PAMP), posing unique challenges in the…pthomsonJune 3, 2022 Read More