Publications of the Week Enteric Neuronal Piezo1 Maintains Mechanical and Immunological Homeostasis by Sensing Force Xie, Z., et al. | April 2, 2025 The gastrointestinal (GI) tract experiences a myriad of mechanical forces while orchestrating digestion and barrier…karnottApril 2, 2025 Read More
Publications of the Week Proliferation History and Transcription Factor Levels Drive Direct Conversion to Motor Neurons Wang, N., et al. | March 24, 2025 The sparse and stochastic nature of conversion has obscured our understanding of how transcription factors…karnottMarch 24, 2025 Read More
Publications of the Week Simultaneous CRISPR Screening and Spatial Transcriptomics Reveal Intracellular, Intercellular, and Functional Transcriptional Circuits Binan, L., et al. | March 21, 2025 Pooled optical screens have enabled the study of cellular interactions, morphology, or dynamics at massive…karnottMarch 21, 2025 Read More
Publications of the Week A Torpor-Like State in Mice Slows Blood Epigenetic Aging and Prolongs Healthspan Jayne, L., et al. | March 19, 2025 Torpor and hibernation are extreme physiological adaptations of homeotherms associated with pro-longevity effects. Yet the…karnottMarch 19, 2025 Read More
Publications of the Week Analysis of Human Urinary Extracellular Vesicles Reveals Disordered Renal Metabolism in Myotonic Dystrophy Type 1 Kumari, P., et al. | March 17, 2025 Chronic kidney disease (CKD) and the genetic disorder myotonic dystrophy type 1 (DM1) each are…karnottMarch 17, 2025 Read More
Publications of the Week Cultivated Autologous Limbal Epithelial Cell (CALEC) Transplantation for Limbal Tem Cell Deficiency: A Phase I/II Clinical Trial of the First Xenobiotic-Free, Serum-Free, Antibiotic-Free Manufacturing Protocol Developed in the US Jurkunas, U., et al. | March 13, 2025 We developed a two-stage manufacturing process utilizing cultivated autologous limbal epithelial cells (CALEC), the first…karnottMarch 13, 2025 Read More
Publications of the Week Meta-Analysis of Genome-Wide Associations and Polygenic Risk Prediction for Atrial Fibrillation in More Than 180,000 Cases Nature Genetics | March 11, 2025 Atrial fibrillation (AF) is the most common heart rhythm abnormality and is a leading cause…karnottMarch 11, 2025 Read More
Publications of the Week Programs, Origins, and Immunomodulatory Functions of Myeloid Cells in Glioma Miller, T., et al. | March 7, 2025 Gliomas are incurable malignancies notable for having an immunosuppressive microenvironment with abundant myeloid cells, the…karnottMarch 7, 2025 Read More
Publications of the Week Granzyme K Activates the Entire Complement Cascade Donado, C., et al. | March 5, 2025 Granzymes are a family of serine proteases mainly expressed by CD8+ T cells, natural killer…karnottMarch 5, 2025 Read More
Publications of the Week LUC7 Proteins Define Two Major Classes of 5′ Splice Sites in Animals and Plants Kenny, C., et al. | March 3, 2025 Mutation or deletion of the U1 snRNP-associated factor LUC7L2 is associated with myeloid neoplasms, and…karnottMarch 3, 2025 Read More