Publications of the Week

Chimeric antigen receptor (CAR) T cells are highly effective in haematological malignancies1. However, progressive loss…

Prime editors make programmed genome modifications by writing new sequences into extensions of nicked DNA…

Loss-of-function variants in the lipid transporter ABCA7 substantially increase the risk of Alzheimer’s disease1,2, yet…

Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by progressive cognitive decline, yet its epigenetic…

Antibody–drug conjugates (ADCs) are effective targeted therapeutics but are limited in their ability to incorporate…

The awakening of dormant disseminated cancer cells appears to be responsible for the clinical relapses…

Chimeric antigen receptor (CAR) T cell therapy targeting CD19 elicits remarkable clinical efficacy in B…

Women with obesity-driven type 2 diabetes (T2D) face worse breast cancer outcomes, yet metabolic status…

Despite the remarkable fidelity of eukaryotic DNA replication, nucleotide misincorporation errors occur in every replication…

Small-cell lung cancers (SCLCs) contain near-universal loss-of-function mutations in RB1 and TP53, compromising the G1–S…