Publications of the Week Single-Cell and Spatial Transcriptomics of Stricturing Crohn’s Disease Highlights a Fibrosis-Associated Network Kong, L., et al. | July 2, 2025 Fibrosis is a major complication of Crohn’s disease (CD) marked by excess deposition of extracellular…karnottJuly 2, 2025 Read More
Publications of the Week ZNF280A Links DNA Double-Strand Break Repair to Human 22q11.2 Distal Deletion Syndrome Clarke, T., et al. | June 26, 2025 DNA double-strand breaks (DSB) are among the most deleterious forms of DNA damage and, if…karnottJune 26, 2025 Read More
Publications of the Week Perturb-Multimodal: A Platform for Pooled Genetic Screens With Imaging and Sequencing in Intact Mammalian Tissue Saunders, R., et al. | June 23, 2025 Metazoan life requires the coordinated activities of thousands of genes in spatially organized cell types.…karnottJune 23, 2025 Read More
Publications of the Week Iterative Transcription Factor Screening Enables Rapid Generation of Microglia-Like Cells From Human iPSC Liu, S., et al. | June 17, 2025 Differentiation of induced pluripotent stem cells (iPSCs) into specialized cell types is essential for uncovering…karnottJune 17, 2025 Read More
Publications of the Week Multi-Timescale Reinforcement Learning in the Brain Masset, P., et al. | June 16, 2025 To thrive in complex environments, animals and artificial agents must learn to act adaptively to…karnottJune 16, 2025 Read More
Publications of the Week Loss of Insulin Signaling in Microglia Impairs Cellular Uptake of Aβ and Neuroinflammatory Response Exacerbating AD-Like Neuropathology Chen, W., et al. | June 12, 2025 Clinical studies have suggested a strong link between type 2 diabetes (T2D) and Alzheimer’s disease…karnottJune 12, 2025 Read More
Publications of the Week Multimodal Cell Maps as a Foundation for Structural and Functional Genomics Schaffer, L., et al. | June 11, 2025 Human cells consist of a complex hierarchy of components, many of which remain unexplored1,2. Here…karnottJune 11, 2025 Read More
Publications of the Week Expansion In Situ Genome Sequencing Links Nuclear Abnormalities to Aberrant Chromatin Regulation Labade, A., et al. | June 9, 2025 Microscopy and genomics are used to characterize cell function, but approaches to connect the two…karnottJune 9, 2025 Read More
Publications of the Week Polygenic Modifiers Impact Penetrance and Expressivity in Telomere Biology Disorders Poeschla, M., et al. | June 5, 2025 BACKGROUND. Telomere biology disorders (TBDs) exhibit incomplete penetrance and variable expressivity, even among individuals harboring…karnottJune 5, 2025 Read More
Publications of the Week Evolution-Guided Protein Design of IscB for Persistent Epigenome Editing In Vivo Kannan, S., et al. | June 3, 2025 Naturally existing enzymes have been adapted for a variety of molecular technologies, with enhancements or…karnottJune 3, 2025 Read More