The shape and size of a grain of rice, the new device can conduct dozens of experiments at once to study the effects of new treatments on some of the hardest-to-treat brain cancers Researchers from Brigham and Women’s Hospital, a founding member of the Mass General Brigham healthcare system, have designed a device that can help test treatments in patients…
Molly Frank of the Lobel Lab, Noah Singer of the Rotjan and Novak Labs, and Michelle Feivelson are this year’s recipients of the Robert E. Hausman Scholarship for continuing MS students. Molly completed her undergraduate degree in conservation biology and zoology in the Midwest, where she worked on a fresh water limnology research project for the Iowa DNR after graduating.…
Several years ago, while working as a clinical geneticist at the Imagine Institute of Genetic Diseases in Paris, Dr. Maya Chopra saw a child with unexplained intellectual disability, a cleft palate, distinctive facial features, and an inability to speak. Through a genetic analysis, she and her colleagues identified a rare variant in one copy of a gene called ANKRD17. Intrigued, Dr. Chopra asked…
A pathological hallmark of Alzheimer’s disease (AD) is the deposition of amyloid-β (Aβ) protein in the brain. Physical exercise has been shown to reduce Aβ burden in various AD mouse models, but the underlying mechanisms have not been elucidated. Irisin, an exercise-induced hormone, is the secreted form of fibronectin type-III-domain-containing 5 (FNDC5). Here, using a three-dimensional (3D) cell culture model…
Koch Institute faculty members Michael Birnbaum, Ömer Yilmaz, Brandon DeKosky and Regina Barzilay, along with their MIT colleague Seychelle Vos, have been selected for the final stages of Cancer Grand Challenges as part of teams MATCHMAKERS, PROSPECT and KOODAC. If selected, these interdisciplinary, global teams may receive up to $25m to make radical progress against some of cancer’s toughest challenges.…
In a phase 3 global clinical trial called FLAURA2 led by researchers from Dana-Farber Cancer Institute and Institut Gustav Roussy in France, patients with non-small cell lung cancer (NSCLC) with an epidermal growth factor receptor (EGFR) mutation taking standard therapy plus chemotherapy had a median of nearly 9 months increase in progression free survival compared with patients taking standard therapy…
Life-long reconstitution of a tissue’s resident stem cell compartment with engrafted cells has the potential to durably replenish organ function. Here, we demonstrate the engraftment of the airway epithelial stem cell compartment via intra-airway transplantation of mouse or human primary and pluripotent stem cell (PSC)-derived airway basal cells (BCs). Murine primary or PSC-derived BCs transplanted into polidocanol-injured syngeneic recipients give…
When Covid-19 began spreading in 2020, some of its most common symptoms affected the peripheral nervous system, the network of nerves that enables communication between the brain and the rest of the body. Many people reported losing their senses of smell and taste, which both rely on sensory neurons in the peripheral nervous system. In the years since, a significant…
Alex Andrew Bohm, associate professor of developmental, molecular and chemical biology at Tufts University School of Medicine and the Graduate School of Biomedical Sciences (GSBS), died August 28. He was 57 years old. Bohm, who went by Andrew, was a beloved member of the Tufts community not only for his decades of teaching and research, but also for his service…
Carl Streed, Jr., MD, assistant professor of medicine, is a recipient of a 2023 40 Under 40 Public Health Catalyst Award from Boston Congress of Public Health. He is part of the second cohort that represents the next generation of leaders, entrepreneurs, researchers, scientists, activists, intellectual provocateurs, authors, and directors who inspire and catalyze us all to a more just…
