Publications of the Week

The awakening of dormant disseminated cancer cells appears to be responsible for the clinical relapses…

Chimeric antigen receptor (CAR) T cell therapy targeting CD19 elicits remarkable clinical efficacy in B…

Women with obesity-driven type 2 diabetes (T2D) face worse breast cancer outcomes, yet metabolic status…

Despite the remarkable fidelity of eukaryotic DNA replication, nucleotide misincorporation errors occur in every replication…

Small-cell lung cancers (SCLCs) contain near-universal loss-of-function mutations in RB1 and TP53, compromising the G1–S…

The rational design of receptor agonists to control cell signaling is an emerging strategy for…

Meiotic failure is a major cause of infertility, but the lack of an in vitro…

The earliest molecular changes in Alzheimer’s disease (AD) are poorly understood1,2,3,4,5. Here we show that…

In vivo CRISPR screens in CD8+ T cells have previously uncovered targets for cancer immunotherapy;…

Parkinson’s disease (PD) is characterized by inclusions of α-synuclein (α-syn) and mitochondrial dysfunction in dopaminergic…