Publications of the Week Neoadjuvant PD-1 and PD-L1 Blockade With Chemotherapy for Borderline Resectable and Unresectable Stage III Non–Small Cell Lung CancerRicciuti, B., et al. | July 4, 2025Is neoadjuvant programmed cell death 1 protein (PD-1) or programmed cell death 1 ligand 1…karnottJuly 4, 2025 Read More
Publications of the Week Single-Cell and Spatial Transcriptomics of Stricturing Crohn’s Disease Highlights a Fibrosis-Associated NetworkKong, L., et al. | July 2, 2025Fibrosis is a major complication of Crohn’s disease (CD) marked by excess deposition of extracellular…karnottJuly 2, 2025 Read More
Publications of the Week ZNF280A Links DNA Double-Strand Break Repair to Human 22q11.2 Distal Deletion SyndromeClarke, T., et al. | June 26, 2025DNA double-strand breaks (DSB) are among the most deleterious forms of DNA damage and, if…karnottJune 26, 2025 Read More
Publications of the Week Perturb-Multimodal: A Platform for Pooled Genetic Screens With Imaging and Sequencing in Intact Mammalian TissueSaunders, R., et al. | June 23, 2025Metazoan life requires the coordinated activities of thousands of genes in spatially organized cell types.…karnottJune 23, 2025 Read More
Publications of the Week Iterative Transcription Factor Screening Enables Rapid Generation of Microglia-Like Cells From Human iPSCLiu, S., et al. | June 17, 2025Differentiation of induced pluripotent stem cells (iPSCs) into specialized cell types is essential for uncovering…karnottJune 17, 2025 Read More
Publications of the Week Multi-Timescale Reinforcement Learning in the BrainMasset, P., et al. | June 16, 2025To thrive in complex environments, animals and artificial agents must learn to act adaptively to…karnottJune 16, 2025 Read More
Publications of the Week Loss of Insulin Signaling in Microglia Impairs Cellular Uptake of Aβ and Neuroinflammatory Response Exacerbating AD-Like NeuropathologyChen, W., et al. | June 12, 2025Clinical studies have suggested a strong link between type 2 diabetes (T2D) and Alzheimer’s disease…karnottJune 12, 2025 Read More
Publications of the Week Multimodal Cell Maps as a Foundation for Structural and Functional GenomicsSchaffer, L., et al. | June 11, 2025Human cells consist of a complex hierarchy of components, many of which remain unexplored1,2. Here…karnottJune 11, 2025 Read More
Publications of the Week Expansion In Situ Genome Sequencing Links Nuclear Abnormalities to Aberrant Chromatin RegulationLabade, A., et al. | June 9, 2025Microscopy and genomics are used to characterize cell function, but approaches to connect the two…karnottJune 9, 2025 Read More
Publications of the Week Polygenic Modifiers Impact Penetrance and Expressivity in Telomere Biology DisordersPoeschla, M., et al. | June 5, 2025BACKGROUND. Telomere biology disorders (TBDs) exhibit incomplete penetrance and variable expressivity, even among individuals harboring…karnottJune 5, 2025 Read More