Neutrophils require the lipid mediator leukotriene B4 (LTB4) to swarm in response to a fungal target. LTB4 is synthesized by neutrophils as they swarm.
Since swarming is a collective behavior, we sought to determine whether neutrophils can cooperate to generate this mediator through a transcellular biosynthetic mechanism, and whether this process can rescue defective swarming behavior for mutant cells not capable of synthesizing LTB4.
