Scientists from the Precision Cardiology Lab (PCL) of the Broad Institute of MIT and Harvard and Bayer have generated detailed maps of a variety of cell types in the heart that are involved in two major causes of heart failure: dilated and hypertrophic cardiomyopathy (DCM and HCM), which both impair the heart’s pumping ability.
The team’s findings, published today in Nature, suggest specific cell types and biological mechanisms that could be targeted by new treatments. Heart failure is one of the most common causes of hospitalization in the United States. Existing drugs are limited and many patients ultimately die from heart failure.
