Aggression is dependent on the sex of the conspecific in almost all animal species. But the neuronal basis of how sex-specific chemosensory signals regulate aggression is poorly understood. Using the fruit fly model of Drosophila melanogaster, we demonstrate that activation of a group of GABAergic central brain neurons, known to respond to sex-specific pheromonal stimuli, enhances aggression in dyadic male encounters. Inactivation of this neuronal group decreases aggression and increases the reciprocal social behavior of courtship. Our results can help trace the neural circuit from pheromone processing in the sensory neurons to behavior integration in the central brain and ultimately help understand how neurons encode the behavior of aggression.
