Our body is teeming with bacteria—in our gut, on our skin, and in every corner of our mouths. What prevents these microbes from getting out of control and causing diseases? Our immune system plays a role, but it’s not acting alone. In recent research, Forsyth Institute scientists in the Bor Lab and collaborators found that a group of bacteria called Saccharibacteria may protect humans against oral pathogens, upending the previously held belief that these microbes are disease-causing.
This discovery opened up a whole new area of exploration in the field of microbiology, and the Bor Lab was granted a 5-year Research Project Grant (R01) from the National Institutes of Health to study these microbes further.
The communities of bacteria that live on and within humans impact our health in ways scientists are just beginning to understand. But even more mysterious are the bacteria that grow on other bacteria. These ultrasmall microbes, known as Saccharibacteria or TM7, are associated with inflammation, suggesting they are somehow linked to our body’s immune response. The new grant will allow Dr. Batbileg Bor, Assistant Member of Staff at The Forsyth Institute and Director of the Bor Lab, to investigate how Saccharibacteria interact with the innate and adaptive immune system and impact the larger microbial community of their environment, using periodontal disease as a model system.
