BUSM researchers have identified that a peptide, pituitary adenylate cyclase-activating mediator of compulsive consumption of alcohol. In addition, they have discovered that this protein acts in an area of the brain called the Bed Nucleus of the Stria Terminalis, or BNST, a region involved in fear, anxiety and stress responses, to exert these effects. Alcohol use disorder or AUD is…
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Kim Lab Receives American Lung Association Research Award

Amid Pandemic, Boston Children’s Hospital’s Stem Cell Program Researcher Receives American Lung Association Research Award To Investigate Using “Organoid” Model of Lung Cancer to Test Treatment. Carla Kim, PhD received one of Lung Association’s 98 research investments to advance the understanding of Using “Organoid” Model of Lung Cancer to Test Treatment. BOSTON (November 16, 2020) – The Stem Cell Program announced…
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STAT set out to celebrate the unheralded heroes of science and medicine, poring over hundreds of nominations from across North America in search for the next generation of scientific superstars. We were on the hunt for the most impressive doctors and researchers on the cusp of launching their careers, but not yet fully independent. This year, as in past years,…
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In Spring 2020, as the world watched the novel coronavirus spread across the globe, Marta Gaglia, an assistant professor of molecular biology and microbiology at Tufts University School of Medicine, had a realization: The very same approaches she had been using to study familiar viruses like influenza and herpes could be applied to SARS-CoV-2, the virus that causes COVID-19. “What…
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Forsyth Launches New Forsyth Oral Microbiome Core

The Forsyth Institute is now offering Next Generation Sequencing (NGS) and comprehensive data analyses and interpretation for 16S rRNA gene amplicon sequences and other big data sequence applications through the new Forsyth Oral Microbiome Core (FOMC). Analyses of previously obtained sequences are also offered. Many investigators are familiar with the Human Oral Microbe Identification using Next Generation Sequencing (HOMINGS) as well as its predecessor…
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Regulating the Regulators

MicroRNAs are short RNA sequences that maintain a tight control on which genes are expressed and when. They do this by regulating which messenger RNA (mRNA) transcripts — the single-stranded templates for proteins — are actually read by the cell. But what controls these cellular controllers? In a new study published Nov. 12 in Science, researchers in David Bartel’s lab at Whitehead…
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In 2019, cancer researchers from MIT found a drug that targeted an elusive molecular interaction previously considered “undruggable.” In so doing, they opened up a new realm of chemotherapy. This drug, called JH-RE-06, sensitized tumors to treatment, but the scientists didn’t fully understand how it exerted its effects. Now, in a pair of studies published in PNAS, the same team is closer to…
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Recent large-scale sequencing efforts have enabled the detection of millions of missense variants. Elucidating their functional effect is of crucial importance but challenging. We approach this problem by performing a wide-scale characterization of missense variants from 1,330 disease-associated genes using >14,000 protein structures. We identify 3D features associated with pathogenic and benign variants that unveiled the mutations’ effect at the…
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A multidisciplinary team of scientists led by Elinor Karlsson, PhD, associate professor of molecular medicine in the Program in Bioinformatics and Computational Biology, has captured biodiversity at a genetic level. By sequencing the genome of 240 mammalian species, 122 of which had never been sequenced, researchers identified a correlation between regions of reduced genetic diversity in species with a higher…
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