The MIT Press has announced the launch of Rapid Reviews: COVID-19 (RR:C19), an open access, rapid-review overlay journal that will accelerate peer review of Covid-19-related research and deliver real-time, verified scientific information that policymakers and health leaders can use. Scientists and researchers are working overtime to understand the SARS-CoV-2 virus and are producing an unprecedented amount of preprint scholarship that is publicly available…
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Still flying high from its major biobucks pact with Gilead Sciences, kidney disease biotech Goldfinch Bio has followed up with a $100 million funding round. Based in Cambridge, Massachusetts, Goldfinch Bio aims to use a precision medicine approach to better treat kidney disease. Its pipeline is based on its Kidney Genome Atlas, a patient registry containing genomic, transcriptomic and proteomic…
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Researchers from the Center for Regenerative Medicine (CReM) have assembled the largest repository of patient derived stem cells (iPSCs) from patients with alpha-1 antitrypsin deficiency (AATD). “Our goal is to get these cells out to other researchers so that they will use them to ultimately help patients with AATD. To do that, we needed to do everything possible to make…
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Alzheimer’s disease (AD) causes unrelenting, progressive cognitive impairments, but its course is heterogeneous, with a broad range of rates of cognitive decline1. The spread of tau aggregates (neurofibrillary tangles) across the cerebral cortex parallels symptom severity2,3. We hypothesized that the kinetics of tau spread may vary if the properties of the propagating tau proteins vary across individuals. We carried out…
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Despite the growing burden and high morbidity and mortality associated with non-alcoholic fatty liver disease (NAFLD), treatments are limited to risk factor modification including lifestyle intervention and management of co-morbid metabolic disease. Using a murine model of NAFLD, BMP signaling was found to be essential for the development of hepatic steatosis, independent of plasma cholesterol levels or glucose tolerance.
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Cambridge, Massachusetts-based Carmine Therapeutics inked a research collaboration deal with Japan’s Takeda Pharmaceutical to develop and commercialize non-viral gene therapies for two rare diseases. Under the terms of the deal, Takeda will pay Carmine an undisclosed upfront payment and research funding support. Takeda has committed to a $5 million convertible loan to support the development of Carmine’s REGENT technology platform. Carmine is also eligible…
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At the heart of Whitehead Institute are its Members, a group of world-class investigators who propel science forward through their research discoveries and technical advances. Recently, Whitehead Institute singled out two Members for special recognition: appointment to endowed professorships, which provide financial support for their research programs and serve as an endorsement of their scientific visions. Whitehead Institute Member Mary Gehring,…
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When neurons fire an electrical impulse, they also experience a surge of calcium ions. By measuring those surges, researchers can indirectly monitor neuron activity, helping them to study the role of individual neurons in many different brain functions. One drawback to this technique is the crosstalk generated by the axons and dendrites that extend from neighboring neurons, which makes it…
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