Dana-Farber Cancer Institute Trustee, M. Dozier Gardner, along with his wife and family, have made a $5 million gift to Dana-Farber to establish the Dozier Gardner Family Fund in support of the Presidential Initiatives Fund. This gift offers flexible support for Dana-Farber President and CEO Laurie H. Glimcher, MD, to direct toward cancer research priorities, and provides powerful momentum toward…
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A group of nine leading pharmaceutical and biotechnology companies pledged on Tuesday to only seek approval for Covid-19 vaccines demonstrated to be safe and effective, an apparent attempt to provide public reassurance despite the widely held view that the Covid-19 vaccine development process is politically tainted. In a statement, the companies pledged to “make the safety and well-being of vaccinated…
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A team of infectious disease and regenerative medicine researchers at Boston University, studying human stem cell-derived lung tissue infected with SARS-CoV-2, are discovering new insights into how the novel coronavirus kicks off a cascade of tissue inflammation in the lungs. That reaction can be especially lethal for older people, who make up 8 out of every 10 deaths from COVID-19,…
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Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has infected over 21 million people worldwide since August 16, 2020. Compared to PCR and serology tests, SARS-CoV-2 antigen assays are underdeveloped, despite their potential to identify active infection and monitor disease progression. Methods We used Single Molecule Array (Simoa) assays to quantitatively detect SARS-CoV-2 spike, S1 subunit, and nucleocapsid antigens in the…
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A targeted therapy called capmatinib can provide significant benefits to patients who have advanced lung cancer with specific gene mutations, according to recently published results from a phase two clinical trial. The trial, which is published in the New England Journal of Medicine, was conducted by an international team led by investigators at Massachusetts General Hospital (MGH). A protein called MET…
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No recent biomedical experiment has caused more consternation than He Jiankui’s creation of the first gene-edited babies, in 2018, which was widely seen as dangerous, unethical, and premature—and which led to his incarceration by China. Now, an international committee has concluded that gene-editing methods, despite substantial improvements, are still far from mature enough to safely introduce heritable DNA modifications into…
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A new research and drug discovery effort at the Broad Institute of MIT and Harvard is taking aim at the rare, inherited movement disorder Friedreich’s ataxia (FA), which causes progressive damage to the nervous system. FA arises from genetic mutations that lead to dysfunction of the cell’s energy-producing organelles called mitochondria. The disorder is the most common mitochondrial disease, and…
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Embedded throughout the gastrointestinal system is an extensive array of neurons that coordinates nearly all activities involved in digestion, gut motility, and response to noxious stimuli. These cells make up the enteric nervous system (ENS) and transmit signals from the gut to the brain, but are rare and fragile, making them difficult to isolate and study. A team led by…
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Lung cancer, the leading cancer killer in the U.S., is often missed in its earlier stages. And while recent imaging advances offer earlier detection, early-stage lung cancers still have no targeted treatments. Key takeaways Mini “organoids” made from lung cells offer a rapid platform for tracking early-stage lung cancers and for testing possible treatments. RNA sequencing findings in the organoids…
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Transcription-translation coupling has long been considered a defining feature of the central dogma in bacteria. However, transcription-translation coupling has largely been characterized in E. coli and other related bacteria. The authors have demonstrated that coupling does not occur in the model gram-positive bacteria B. subtilis. Instead, in this bacterium, transcription is much faster than translation, allowing the RNA polymerase to ‘run away’ from the ribosome.
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